Three teams will look to remain unbeaten in Week 6, while four other clubs will attempt to break into the win column for the first time in 2013.
In the AFC West, the undefeated Denver Broncos and Kansas City Chiefs will each be favored to win big at home over the Jacksonville Jaguars and Oakland Raiders, respectively. The two heavyweights are neck-and-neck for the division lead through five weeks and are sure to stay that way until their first meeting in Week 11 in Denver.
They'll square off in Kansas City two week later in another high-stakes matchup.
But the Broncos and Chiefs aren't the only teams guaranteed to prevail this weekend.
The Seattle Seahawks are double-digit favorites over the Tennessee Titans in Week 6—and for obvious reasons. After all, Pete Carroll's Hawks are 10-0 at home since the start of 2012 and outscoring opponents by 27 points at CenturyLink Field this fall.
Plus, while the Titans boast a quality defense, their offense is struggling to find balance. They rank 26th in the league in passing yards, which doesn't bode well considering they're set to go up against the NFL's third-ranked secondary in terms of fewest yards allowed.
There's also the turnover factor. The Titans had zero giveaways through their first four games but had three in Week 5's loss. Seattle is tied with Kansas City for the most takeaways this season, forcing an average of three turnovers per game.
In the end, there's no greater home-field advantage in football than in Seattle, where the 12th man powers the Seahawks not only to wins but also to routs.
San Francisco 49ers
Another NFC West contender set to roll this weekend is San Francisco. The 49ers have steadied the ship after a surprising 1-2 start.
In Week 6, the Niners will host the Arizona Cardinals, who, despite their 3-2 record, appear poised to collapse in the coming weeks. Keep in mind that Arizona has been feasting on the NFC's bottom feeders, beating the winless Buccaneers on the road and topping the Panthers in the desert.
Meanwhile, San Francisco has rediscovered its swagger following back-to-back blowout victories. The offense has put up at least 34 points in each of the two wins, and the defense has brought back memories of last year's unit, generating turnovers and keeping opponents out of the end zone.
Expect the Niners defense to terrorize Cards quarterback Carson Palmer, who has thrown nine picks in 2013, including seven since Week 3. Consequently, the San Francisco offense won't need to be dominant in order to pull out a third straight win.
The Dallas Cowboys proved to be the NFC East's best in Week 5, hanging 48 points on the Denver Broncos and nearly coming away with a monumental upset. But even at 2-3, Dallas should be a heavy favorite against rival Washington in Week 6.
Neither team is playing well defensively in 2013, but the Redskins defense has been shockingly horrible in all facets of the game to start the year.
Teams are throwing and running wherever they want against Washington, so expect Dallas to do the same inside Jerry's World, where the Cowboys are averaging over 38 points per game this season.
Washington will have the advantage of coming off a bye week, but with Robert Griffin III presenting much less of a threat with a bulky knee brace slowing him down, it's difficult to imagine Washington's offense keeping pace with Tony Romo and his plethora of downfield weapons.
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