When making your picks for Week 5, it's best to proceed with caution. Things could get a little weird.
Even though we've seen just about every team play the first quarter of its schedule, it's safe to say that some teams have played above their means while others have struggled to live up to their potential.
That's a recipe for more than a few eyebrow-raising results on Sunday afternoon.
Here's a full look at the slate along with the favorites who could get more than they bargained for on Sunday.
Kansas City Chiefs Traveling to the Jake Locker-less Tennessee Titans
The Kansas City Chiefs have been awfully impressive in going 4-0, but expecting them to waltz into Tennessee and easily handle the Titans may be a tall order.
Yes, the Titans will be without Jake Locker. He's expected to miss four to eight weeks according to ESPN. But the fact of the matter is that that Locker's improved play this year is only part of the reason the Titans are 3-1 this season.
The defense is ranked No. 7 overall in terms of scoring and is equally adept at stopping the pass (10th in the league) and run (11th).
The Chiefs have a strong defense of their own, but this one should be a slugfest.
Seattle Seahawks Going to Indianapolis to Take on the Red-Hot Colts
The common way to look at this game is that the Seahawks are probably the second-best team in the NFL. The Colts are not. Therefore, the Seahawks should be favored regardless of where this game is being played.
While that's true, it's also true that this game is being played in Indianapolis. The Seahawks have looked significantly less impressive on the road than they have at home and looked very mortal against the Houston Texans last week.
With the Colts coming off of back-to-back wins on the road against the San Francisco 49ers and Jacksonville Jaguars, there are few teams that have looked as dominant in the last two weeks. The Seahawks may not be among the ranks of the undefeated when this one is over.
San Diego Chargers Taking on the Oakland Raiders on the Road
Just like the other two teams on this list, the San Diego Chargers deserve to be favored. But it's not going to be easy for them to live up to expectations.
Philip Rivers' play at quarterback this season should have Chargers fans excited. He has the second-highest quarterback rating in the league. However, the defense should have fans frustrated. It ranks 29th against the pass and 26th against the run.
That's simply not good enough for the Chargers to be a huge favorite over anyone.
According to Adam Schefter of ESPN, Terrelle Pryor is expected to return to the Raiders lineup after missing the team's 24-14 loss to the Washington Redskins. That means the Raiders will have a quarterback who is able to make some plays and keep the Raiders in the game throughout.