After facing mostly provincials, Rudi Garcia's team were up against a revitalized Inter side that has had a makeover under new coach Walter Mazzarri.
However, Roma's new high-flying offense was too much for the Nerazzurri to deal with as goals from Francesco Totti, Gervinho and Alessandro Florenzi would get them all three points.
Without further ado, here are five things we learned from this pivotal Serie A fixture.
The fact that a Frenchman had to be the one to teach an Italian side how to defend is incredible enough, but the way he has molded Roma has been nothing short of spectacular.
Garcia's Giallorossi have won all seven of their first domestic matches and lead the Serie A table.
More than anything, the players look happy and are coming together to create enviable chemistry.
Gervinho has been the surprise of the Summer after joining from Arsenal following a few disappointing years where he failed to recreate his sparkling form from Lille.
Ironically, the man who coached him during his best years in Ligue 1 happens to be the same person that desperately wanted him during the Summer—Rudi Garcia.
Apart from scoring goals, Gervinho's close quarter dribbling and stunning change of pace with the ball at his feet has been creating a nightmare for opposing defenders.
After losing against Roma, Inter are now fourth in Serie A. The entire situation could bring back memories of last year when former coach Andrea Stramaccioni guided his team to a stellar first half of the season, only to fall to mid-table mediocrity at the end.
Mazzarri's team is already dealing with a slew of injury issues and are desperate for the return of their defensive pillar, Hugo Campagnaro.
It's a precarious situation for any manager to deal with, coming to a new club as a foreigner when one of the players has an almost godlike status in the entire city.
Francesco Totti is bigger than the club itself. There have been rumors in past years about the player being a key component to certain players and coaches getting the axe from the club.
However, everything looks serene, as everything points towards the club's captain and French coach Rudi Garcia getting along on perfect terms.
If there's one thing fans can take away from this fixture, it's that Roma are the real deal.
The Giallorossi have not only won each of their first seven matches in Serie A, but play some of the most aesthetically pleasing football in Europe.
They are just as comfortable in possession as they are darting on the counter attack.
Roma has to now be considered a Scudetto favorite only a few weeks after there were doubts about them even finishing top five in a highly competitive Serie A where the teams at the top reinforced themselves in the Summer.