After getting hit on an attempted scramble in the first quarter, Hoyer looked shaken up and headed to the locker room. According to the Cleveland Browns' Twitter account, it was a knee injury, and his return to the game is questionable.
This is not good news for fantasy owners who have Gordon or Cameron in their lineup.
Gordon has had over 210 yards receiving to go along with a touchdown since coming back from a suspension, with Brian Hoyer targeting him 14 times over the past two games. He's clearly been the go-to receiver on offense.
Meanwhile, Cameron has been a huge red-zone threat for Hoyer. He's had 16 receptions over the past two games with Hoyer in the lineup, grabbing 16 receptions for 157 yards and four touchdowns.
With Brandon Weeden back in the lineup, things aren't going to be pretty. Weeden holds onto the ball much longer than Hoyer, who learned behind Tom Brady for the past couple of seasons. Before this game against the Bills, he was completing just 54.7 percent of his passes with one touchdown and three interceptions for a passer rating of just 62.0.
Hoyer was able to make plays through the air and lead this team to two wins, but with him out and Weeden back in, the Browns' two big playmakers are going to struggle to put up points.