LeSean McCoy, Philadelphia Eagles
Given the status of the Giants defense, McCoy should have a field day in New Jersey this Sunday.
Matt Forte, Chicago Bears
Forte is getting it done this year and is coming off a game in which he ran for95 yards and a touchdown against the Lions. A juicy matchup at home against the Saints makes Forte a fantastic option this week.
Marshawn Lynch, Seattle Seahawks
“Beast Mode” should have little trouble racking up the yardage against the Colts. Lynch is coming off a great performance in Houston, in which he ran for 98 yards and a touchdown, while also hauling in three receptions for 45 yards.
Jamaal Charles, Kansas City Chiefs
Charles did it all on Sunday versus the Giants (65 rushing yards; 62 receiving yards and a touchdown) and he should be a great option again this week in Tennessee.
Reggie Bush, Detroit Lions
Bush shook off the rust after sitting out last week with an injury and returned in emphatic fashion, rushing for 139 yards and a touchdown (along with four receptions for 34 yards) against the Bears. Now back healthy, Bush is a no-brainer selection this week when the Lions take on the Packers.
Arian Foster, Houston Texans
After some early season struggles, Foster returned to prime-time status this past week after rushing for 102 yards and reeling in six receptions for 69 yards and a touchdown against the vaunted Seahawks defense. Foster will not have it any easier, though, when the Texans visit the 49ers this week.
Frank Gore, San Francisco 49ers
Gore is coming off a spectacular outing versus the Rams when he ran for 153 yards and a touchdown. Gore remains the heart and soul of the 49ers offense, and they’ll be sure to feed him early and often against the Texans.
DeMarco Murray, Dallas Cowboys
While the Broncos (Dallas’ Week 5 opponent) do a great job limiting the rush, Murray is still an integral part of what the Cowboys do on offense.
Bilal Powell, New York Jets
Powell has seized control of the Jets backfield and is coming off a decent outing (66 rushing yards, three receptions for 42 yards) against the Titans. Powell should do just well enough against the Falcons on Monday night to be recommended No. 2 RB (or very low-end No.1) this week.
Ray Rice, Baltimore Ravens
Rice’s ranking here depends on his ability to stay healthy. Although he had an awful outing against the Bills on Sunday (five carries for 17 rushing yards), if he can show that he is healthy, he still makes for a recommended play against the Dolphins in Miami this week, as does Bernard Pierce.
Trent Richardson, Indianapolis Colts
While he did a good job running on the Jags (60 yards and a touchdown), Richardson will find the sledding much tougher when the Seahawks come to town this week.
Darren Sproles, New Orleans Saints
The PPR beast is clearly the best weapon in the Saints backfield and he is coming off a super effort on Monday night (28 yards rushing and a touchdown; seven receptions for 114 yards and a touchdown). Even if you’re not in a PPR league, Sproles should make enough plays against the Bears to warrant a starting spot this week.
Chris Johnson, Tennessee Titans
Johnson had an awful day against the Jets (15 carries for 21 yards), but if the Titans have ideas of beating Kansas City this week, they are going to have to lean on Johnson since backup quarterback Ryan Fitzpatrick is starting his first game of the season.
Lamar Miller, Miami Dolphins
If the Dolphins fed Miller the ball more, he would be higher on the rankings. As it is, Miller is still a solid No. 2 running back.
DeAngelo Williams, Carolina Panthers
Well-rested after the bye week, Williams should be a trusted back to lean on given the fact that he has rushed for at least 85 yards in each game this year (120 against the Giants in Week 3). The Cardinals (the Panthers' Week 5 opponent) are tough against the run, but Williams should still make it onto your squad as a starter nonetheless.
Giovani Bernard, Cincinnati Bengals
The multi-purpose rookie back is still a little rough around the edges, but Bernard is the most explosive playmaker in the Bengals backfield. He has a decent matchup with the Patriots coming to town this week.
Knowshon Moreno, Denver Broncos
The game between the Broncos and the Cowboys has the makings of a shootout, and surely Moreno shall make his presence felt in this affair.
Eddie Lacy, Green Bay Packers
Now that he’s a full go after his concussion, Lacy should get a lot of touches when the Lions visit Green Bay this week.
Danny Woodhead, San Diego Chargers
If you’re in a PPR-league, Woodhead is now bordering on a must-start. If not, Woodhead is still a solid start, since Rivers is looking at Woodhead a lot in the passing game. This week against Oakland, Woodhead could put up some overall crooked numbers.
Maurice Jones-Drew, Jacksonville Jaguars
MJD is skating on thin ice in fantasy circles. With the Jags struggling mightily, opposing teams have been taking out Jones-Drew. If he can’t get going against the Rams this week, he might turn into a prime-sit candidate.