The short week does not give Harbaugh and his coaching staff much time to sort out and fix the problems that have plagued the 49ers. Both of these teams have a 1-2 record, but the Rams are not to be taken lightly.
In their games last year, the two teams played to a 24-24 tie, then the Rams defeated the 49ers, 16-13.
Jeff Fisher, the head coach of the Rams is known for building tough, physical defenses, but the Rams have allowed 89 points in only three games. Offensively, the Rams are a work-in-progress, as they are trying to replace former stars Steven Jackson and Danny Amendola.
The 49ers are battered and bruised as several key defensive players are likely out. Unlikely to play are Patrick Willis, Ian Williams and Nnamdi Asomugha. Offensively, Vernon Davis has been battling a hamstring injury, and his status is uncertain.
In addition, Aldon Smith is out indefinitely, as he fights to regain control of his life.
The 49ers came into the season already missing Michael Crabtree, Mario Manningham and Chris Culliver, so the loss of these additional players against the Rams is a huge hurdle.
If the 49ers hope to be in the thick of the playoff race, this is a critical game for them. Let's take a closer look at some of the key matchups that will determine the outcome of the game.
*All individual stats are courtesy of Pro-Football-Reference.com. Team stats are courtesy of 49ers.com and stlouisrams.com.