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Liverpool's teamsheet may have raised an eyebrow or two when recognised centre-backs Kolo Toure and Mamadou Sakho were selected to fill the right-back and left-back roles, respectively.
Rodgers decided on Martin Skrtel and the fit-again Daniel Agger to occupy the two central-defensive positions yet opted for Toure and Sakho at full-back, despite naming Martin Kelly, Andre Wisdom and Jose Enrique amongst the substitutes.
Toure has been impressive since his switch from Manchester City but looked uncomfortable when ousted from his natural position.
He was on more than one occasion caught in possession and it was his mistimed clearance from a Southampton throw-in that gifted the Saints the corner from which Lovren headed home.
By choosing not to deploy any recognised full-backs, Rodgers side appeared unable to demonstrate the style of football he has worked so tirelessly to implement.
The "play the ball out from the back" method that has at times this season looked very effective was noticeable by its absence as both Toure and Sakho failed to go wide when goalkeeper Simon Mignolet was looking for options.
The Reds caused themselves numerous problems by repeatedly surrendering possession in their own half and as a result found themselves on the back foot.
Wisdom, admittedly did not have the best of games during the 2-2 draw with Swansea yet still appears a more reliable option than Toure at right-back. That is not taking anything away from the Ivorian's ability in his favoured centre-back position.
Jose Enrique, on the other hand, must have wondered what he had done wrong. The Spaniard has been both defensively and offensively sound during the Reds' winning start to the new season yet found himself ousted to incorporate Sakho.
To ensure his side maintain their positive start Rodgers needs to pick his best team and not just his best 11 players—meaning unless ravaged by injuries, only two from Skrtel, Agger, Toure and Sakho should start.