There's always a week when a fixture will creep up on you and leave you wondering how you could be so stupid as to let it pass by. There's a couple of them in Week 6 that every fantasy manager should be aware of, and the defenders will be the ones to suffer.
Vincent Kompany, Manchester City
The key here is to watch Vincent Kompany's performance as he returns from injury to face Manchester United. If he shows some rust, it would be best to keep him out for another week as City travel to Aston Villa.
Villa have already shown that they can compete with the top teams by defeating Arsenal on the opening week of the season.
Kompany is a huge player for City, and at full strength, he should be considered every week. However, a player returning from injury is always a doubt, so Kompany should be assessed closely in the Manchester derby and a complete analysis of his performance made before making any rash decisions.
Jan Vertonghen, Tottenham Hotspur
Jan Vertonghen and Spurs face off against Chelsea in Week 6, but don't be fooled by Jose Mourinho's underperforming team. Chelsea are going to be thirsty for a victory against their London rivals, and the likelihood of Spurs keeping a clean sheet is quite low.
Vertonghen has been impressive for Tottenham this year, and the fans will need another huge performance from him to emerge with a win at White Hart Lane.
Ultimately, it's likely to be a step too far for Vertonghen, and Chelsea should emerge with the points.
Fabricio Coloccini, Newcastle United
Fabricio Coloccini is one of the few reliable cogs in the Newcastle machine, and usually a pretty safe fantasy bet. However, a trip to Everton is going to be difficult for the Magpies, and it's impossible to predict how they're going to play from week to week.
Supporters are angry about the lack of new signings, and the team needs consistent wins to avoid a Toon Army mutiny.
Unfortunately, Alan Pardew is renowned as a manager who goes into away games attempting to not lose them, rather than win them. This tactic is unlikely to work against an Everton side that just polished off Chelsea in Week 4.
Although that win was the Toffees' first of the season, it's unlikely that Pardew will order his team to attack from the outset.
Expect Everton to control possession, putting Coloccini and Newcastle under early pressure from which they are unlikely to recover. The Argentinian can only do so much, and his defence remains fragile.