The 49ers and Colts share two additional things in common. They have both been hit hard by injuries. The 49ers have already been dealing with injuries to Michael Crabtree, Mario Manningham, Ian Williams and Chris Culliver. The Colts have lost running back Vick Ballard and tight end Dwayne Allen.
The second thing these teams have in common is they both feature outstanding young quarterbacks. The 49ers' Colin Kaepernick took his team to the Super Bowl last season. The Colts' Andrew Luck has orchestrated one of the quickest revivals in the NFL.
Kaepernick and Luck are the unquestioned leaders of their respective offenses.
The winner of this game is in solid position, but the loser will have an uphill climb to put itself back in the thick of the playoff discussion.
Let's look at some of the most interesting personnel battles that will go a long way toward deciding the outcome of this game.
All stats are courtesy of Pro-Football-Reference.