San Francisco 49ers vs. Indianapolis Colts Betting Odds, Preview, Prediction

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San Francisco 49ers vs. Indianapolis Colts Betting Odds, Preview, Prediction
Otto Greule Jr/Getty Images

San Francisco barely weathered the storm in the Seattle sky Sunday and had no chance of weathering the storm on the field.

The defending NFC champs came away from Sunday night's 29-3 road loss to the Seahawks humbled and must regroup for a visit from the Indianapolis Colts, who also suffered a Week 2 loss.

San Francisco opened as a 10-point favorite in the 4:25 p.m. ET kickoff but was bet up to -11.5 as of Thursday. The line is not a positive indicator for Colts fans, as their team has not won as a double-digit underdog since 2002, according to OddsShark.com's NFL database.

And there's a bit more than regrouping from the embarrassing loss on national television to what might as well be deemed the odds-on favorite to win the NFC. The 49ers sustained several injuries in a game in which they had five turnovers and no touchdowns for just the third time since 1979, according to Sports Illustrated.

It was also the first time San Francisco had more turnovers than points since former quarterback Alex Smith's first start as the No. 1 overall pick in 2005, a 28-3 loss tosurprise, surprisethe Colts, on October 9 that year.

On the heels of facing young Russell Wilson, next up for the 49ers' depleted defense is another top young quarterback, San Francisco coach Jim Harbaugh's former Stanford QB Andrew Luck, who may have more time than expected in the pocket.

San Francisco has been left with little depth on the defensive line, as Lamar Divens and Will Tukuafu were waived injured and can't be re-signed until later in the season. Defensive tackles Quinton Dial and Tank Carradine won't be available until after Week 6 because they are on the reserve/non-football injury list.

On offense, Colin Kaepernick looked sloppy against Seattle, completing 13 of 28 pass attempts for 127 yards passing and rushing for another 87 yards. In addition, the Seahawks limited Frank Gore to just 16 yards rushing on nine carries and Anquan Boldin to one catch with 9:40 left in the game.

All that, and then there are the mistakes: The 49ers have committed 23 penalties in two games for 206 lost yards.

The betting numbers don't help the Niners, either, as the road team has covered the spread the past four meetings.

Computer Pick: 20-11 Colts (we personally feel the OddsShark.com computer has fallen and bumped its head to come up with that prediction)

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