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Targets are the most obvious stat to focus on beyond receptions, touchdowns and yards. Targets don't have an actual impact for fantasy owners, but they are an excellent way to determine whether a player's current level of production is sustainable over the long haul (or if his production is likely to increase).
For example, look at James Jones. He was targeted 98 times, catching 64 passes for 784 yards and an NFL-leading 14-touchdown receptions in 2012. That's a touchdown for every seven targets. To put that into perspective, Eric Decker, who was second in the NFL with 13 touchdown receptions, had one for every 9.5 targets.
The point is, Jones' usage in the Packers offense makes it really unlikely he'll come anywhere close to catching 14 touchdown passes again this year.
Here's another way of looking at it. In Week 1, Pierre Garcon had seven catches for 64 yards, not exactly a huge day for fantasy owners. But he did have 11 targets, a potential signal of big things to come. So what happened?
Sure enough, in Week 2, he had eight receptions for 143 yards and a touchdown. He only had two more targets, but his production skyrocketed.
Again, targets are generally a pretty good indicator of what is to come, or what production may not be sustainable. Touchdowns and yards can be fickle for receivers, but if a quarterback is consistently looking their way, you can bet the numbers will eventually follow.