This Week 3 matchup promises to be a great one as two 1-1 teams try to double their win total.
The San Francisco 49ers suffered a tough loss on the road in Week 2 against their division rivals, and will look to show the league that Week 2 was the anomaly, not Week 1.
For the Colts, there's plenty to prove as well, as their win in Week 1 came down to the wire against the Oakland Raiders. Yes, you read that right, a close one against the Raiders.
Check out the video above as NFL analysts Aaron Nagler and Matt Miller break down the game and tell you who they think will win. Who do you think wins this one? Let us know in the comments below!