The Broncos have won the last three meetings with Oakland and should be heavily favored to make it four in a row.
Here are my stat predictions for the key offensive players for the Broncos.
Season Stats: 57-of-85 passing, 769 yards, 9 touchdowns, 0 interceptions
But has there been a better player so far this season than Peyton Manning?
Through two games, Manning looks extremely comfortable in Adam Gase's new uptempo offense, and he should have no problems shredding the Raiders secondary.
Manning has so many weapons to choose from, and it will be hard for Oakland to match up with all of them.
One thing to keep an eye on is the status of left tackle Ryan Clady. He is almost certainly out for the game against Oakland and will likely be out much longer, according to Mike Klis and Mike Chambers of The Denver Post.
Chris Clark will get the start in Clady's absence, and he will be tested early. Oakland is tied for the league lead with nine sacks this season.
Prediction: 29-of-38 passing, 424 yards, 4 touchdowns, 0 interceptions
Season Stats: 22 carries, 121 yards, 2 touchdowns, 6 catches, 51 yards
Against the New York Giants, the Broncos opened the second half by running the ball, and in doing so, they may have revitalized the career of Knowshon Moreno.
Moreno ran for 93 yards and had touchdown runs of 20 and 25 yards. Not only that, he provides Peyton Manning with another target in the passing game.
Moreno was given the most snaps in the season opener against Baltimore, largely due to the fact that he is the best pass-blocker of any of the team's running backs.
Suddenly, he clearly seems to be the best option at running back for Denver.
Against the Raiders, the Broncos will likely turn to Moreno often and look to establish a solid rushing attack again. He should see plenty of touches.
Prediction: 16 carries, 85 yards, 1 touchdown, 4 receptions, 24 yards
Season Stats: 20 carries, 40 yards, 2 receptions, 27 yards
Montee Ball is still trying to find a clear role in the Denver offense, but his first-quarter fumble as the Broncos were going in for a score against New York didn't help his cause.
He is still a young player who is very much a work in progress, but the Broncos aren't going to give up on him that easily.
With the hot hand belonging to Knowshon Moreno at the moment, he will likely see the most carries on Monday night, and Ball will probably be used sparingly.
Prediction: 4 carries, 23 yards, 1 catch, 8 yards
Season Stats: 5 carries, 18 yards, 2 receptions, 27 yards
Remember when Ronnie Hillman was supposed to be the starter coming into the season? Those days seem long gone now.
Through two games, Hillman has been given just five carries. It seems clear that his fumbling problems in the preseason have put him out of favor with the coaching staff.
Still, Hillman has plenty of value if the Broncos call his number. However, against Oakland, they probably won't call it much.
Prediction: 2 carries, 11 yards
Season Stats: 12 receptions, 106 yards, 3 touchdowns
Wes Welker has scored a touchdown in both of the Broncos games so far, and to this point, he seems to be every bit the player the Broncos hoped they were getting when they signed him in the offseason.
Welker will be a tough matchup for the Raiders who will counter with someone like Mike Jenkins, D.J. Hayden or former Denver cornerback Tracy Porter.
Welker should have an excellent game against this defense.
Prediction: 7 receptions, 97 yards, 2 touchdowns
Season Stats: 10 receptions, 213 yards, 2 touchdowns
After exploding for 161 yards and two touchdowns against Baltimore, Demaryius Thomas was held to just 52 yards receiving against the New York Giants.
Manning will look to get his No. 1 target back on track against Oakland, and the Raiders don't have anyone who will be able to match up with the physical Thomas.
Look for Manning to dial up a deep ball or two for Thomas in this game.
Prediction: 6 receptions, 122 yards, 1 touchdown
Season Stats: 11 receptions, 119 yards
After being held to just two receptions by Baltimore, Eric Decker led the Broncos with nine catches against the Giants.
The Broncos favored throwing a bubble screen to Decker against New York, and if the Raiders give that to them, they'll go right back to it.
The number of receptions Decker has against Oakland should be somewhere between the two he got against Baltimore and the nine he had against New York.
Prediction: 6 receptions, 80 yards
Season Stats: 2 receptions, 64 yards, 1 touchdown
The Broncos have found a way to get Andre Caldwell involved in the offense this season, and though he only has two catches, that's more than he had all of last season.
Those two catches were virtually on the same play, one against Baltimore that went for a touchdown and another against the Giant—a 36-yard gain.
The Broncos will probably call that play against Oakland as well. After all, it has a high success rate through two games.
Prediction: 1 reception, 32 yards
Season Stats: 11 receptions, 157 yards, 3 touchdowns
The Broncos have an excellent wide receiving corps, but tight end Julius Thomas may be the toughest guy for opposing defenses to match up with.
The Raiders will have two games worth of film to try and prepare for Thomas, but they will also be without safety Tyvon Branch.
That doesn't bode well for the Raiders, and because of that, Peyton Manning should be able to hook up with Thomas down the middle of the field a few times.
Prediction: 4 receptions, 61 yards, 1 touchdown
Season Stats: 2-of-2 field goals, 12-of-12 extra points
Matt Prater remains one of the more reliable kickers in the league, and he hasn't missed a kick of any sort through two games.
Against the Raiders, he won't be called upon for a game-winning kick because Denver should win this one comfortably, but he should tack on plenty of points with his leg.
Prediction: 2-of-2 field goals, 5-of-5 extra points