For Colin Kaepernick, Sunday night's tilt against the Seahawks started badly and only got worse from there, as the second-year starting quarterback served up a career-high three picks against the 49ers' current archrivals.
But there's no reason to believe that the dual-threat standout won't bounce back in a big way and get the 49ers back on track, especially against Indy.
That's because the Colts have had a great deal of trouble defending against the run, as Chuck Pagano's team ranks 29th in the league in that regard, which is certainly good news for Kaepernick and Jim Harbaugh's squad.
Two weeks ago, Indy gave up 112 yards on the ground to Terrelle Pryor during their win against the Raiders, and given Kaepernick's track record, who can possibly say that he doesn't stand a very, very good chance of exceeding that in Week 3?
Even during the loss to the Seahawks, Kaepernick may not have been his usual self when throwing the ball, but he was still by far San Francisco's most effective force on the ground, racking up 87 yards on nine carries. And despite his ugly passing stats, Harbaugh recognized his quarterback's contributions, according to Matthew Barrows of the Sacramento Bee:
"There was good coverage. There was pressure at times," Harbaugh said. "I thought, when we go back and look at the tape, Colin competed, was seeing the field, made plays, made the most amount of plays that we made on offense. … He probably played the best, (was the) most productive person we had on offense."
So, if Kaepernick was capable of coming within breathing distance of a 100-yard rushing effort against a vaunted defense such as that of Seattle's, imagine what kind of damage he'll do against the Colts.
A year ago, Kaepernick shrugged off the pressure of being a guy that was handed the task of maintaining the status quo while then-starter Alex Smith was on the shelf, and the former Nevada star exceeded even Harbaugh's wildest expectations.
And even if the Colts somehow neutralize Kaepernick's ability to march (or rather, sprint) the ball downfield with his legs, as he showed us once again during Week 1 against Green Bay, he's more than just a glorified running back under center, as he threw for 412 yards and three touchdowns against a quality opponent.
On Sunday, Kaepernick will get back to being the absurdly dangerous signal-caller that he is, and though it seems more than likely that he'll do the majority of his damage on the run, he's more than capable of leading the 49ers back above .500 with his arm.
Either way, he'll rebound to lead San Francisco to a much-needed win at Candlestick Park.