NFL Picks Week 3: Breaking Down the Weekend's Biggest Games

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NFL Picks Week 3: Breaking Down the Weekend's Biggest Games
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After so many unexpected results through the first two weeks of the 2013 NFL schedule, Sunday of Week 3 should prove to be something of a moving day for teams across the league. 

There have been teams, initially thought to be average, that have gone 2-0. On the other hand, there have been potential postseason contenders that have stumbled their way to 2-0. And there is also a heap of teams that are stuck at 1-1, so this weekend's slate of games should provide us with some clarity as to which teams are actually capable of making noise this winter. 

With 14 games on tap for Sept. 22, here's a look at how each of Sunday's biggest clashes will end up. 

Game Pick
Kansas City at Philadelphia Chiefs
Green Bay at Cincinnati Packers
St. Louis at Dallas Rams
San Diego at Tennessee Chargers
Cleveland at Minnesota Vikings
Tampa Bay at New England Buccaneers
Arizona at New Orleans Saints
Detroit at Washington Redskins
New York Giants at Carolina Giants
Houston at Baltimore Texans
Atlanta at Miami Falcons
Indianapolis at San Francisco 49ers
Buffalo at New York Jets Bills
Jacksonville at Seattle Seahawks
Chicago at Pittsburgh Bears
Oakland at Denver Broncos

Indianapolis Colts at San Francisco 49ers

In a very intriguing tilt featuring two teams that earned postseason berths last season, the 49ers and Colts will both be looking for redemption after tough Week 2 losses. 

Otto Greule Jr/Getty Images

For San Francisco, this game is an absolute must-win, because the embarrassing defeat the Seahawks handed Jim Harbaugh's team was a humbling result for a team that once again entered the season with Super Bowl aspirations. 

But at the other end of the field, Andrew Luck will be hungry to avoid going 1-2, especially after being stopped cold by Miami's defense in the dying moments of Indy's loss to the Dolphins. 

While Luck is a special playerone that's always capable of lifting his Colts to victory with a standout performancethe odds are stacked heavily against Chuck Pagano's boys. 

One major factor working against them is their lack of success defending the run thus far, so Colin Kaepernick should be able to continue marching down the field with relative ease, and Frank Gore may be due for a bounce-back performance after two disappointing showings. 

One has to assume that Kaepernick will rebound from his three-interception, 13-of-28 passing performance against Seattle. And if he does, the Colts will be in trouble. 

Prediction: 49ers 34, Colts 21

Houston Texans at Baltimore Ravens

When the 2-0 Texans head to M&T Bank Stadium to face the defending Super Bowl champs, both teams will be looking to send a message to a fellow AFC power, so it should be a very emotional contest. 

That'll be especially true if Ed Reed takes the field for Houston, as the longtime Baltimore star will be looking to prove to his former team that they were wrong for letting him leave following the Ravens' championship parade. 

Jeff Gross/Getty Images

Both Joe Flacco and Matt Schaub are more than capable of putting on a show offensively, but the two quarterbacks could be without key targets if Ravens running back Ray Rice and Texans wide receiver Andre Johnson are unable to go on Sunday. 

Last season, the Texans handed the Ravens an embarrassing 43-13 defeat in Houston, so John Harbaugh will have his team fired up for this game. 

If Johnson and Rice are out, both teams have relatively capable replacements in DeAndre Hopkins and Bernard Pierce, respectively, so it may not make much of a difference in terms of the game's outcome. 

Patrick McDermott/Getty Images

But ultimately, the Ravens' 26th-ranked pass defense won't be enough to contain Schaub, Hopkins, Owen Daniels and, potentially, Johnson, so the Texans will steal one on the road. 

Prediction: Texans 31, Ravens 23

Detroit Lions at Washington Redskins

The only reason this is an important game is simple: if Robert Griffin III and the Redskins can't rebound against the Lions, a loss at home against Detroit might as well be the final nail in the coffin on Washington's season. 

Through the first two weeks of the season, the Redskins have looked nothing like the 10-6 team that reeled off seven-straight wins to win the NFC East crown last year. 

And for the Lions, this game represents an opportunity to continue to build momentum going into a pair of vital games against NFC North opponents (Chicago and Green Bay), especially after last weekend's disappointing loss to Arizona. 

Win McNamee/Getty Images

If the Redskins can manage to not play their way out of the game by halftime, RG3, Alfred Morris and Pierre Garcon have a chance at keeping pace with Matthew Stafford, Calvin Johnson and the Lions' attack, especially if Reggie Bush is unable to go. 

Either way, this game is far more important to Washington than it is to the Lions, so anything less than a win at FedEx Field is unacceptable. My guess is that they'll rebound to squeak one out against Detroit's struggling run defense. 

Prediction: Redskins 24, Lions 23

Atlanta Falcons at Miami Dolphins

Before the season began, Miami would have been considered a heavy underdog against Matt Ryan and the mighty Atlanta Falcons because the Dolphins seemed to be stuck in rebuilding mode. 

However, after wins over the Colts and Browns to start the year, the Dolphins enter Sunday's home game against Atlanta at 2-0. However, this week's tilt will easily be their toughest contest yet. 

Yes, Ryan Tannehill's growth as a starting quarterback has been undeniable, especially after outplaying (or at least keeping pace) with Andrew Luck in Week 2. But is anyone really confident that he'll be able to put more points on the board than Matty Ice, Julio Jones and Tony Gonzalez, even if Roddy White continues to be hampered by an ankle injury?

Tannehill and Wallace finally managed to put up big numbers together against Indy, and they'll have to do the same on Sunday if this offense is going to outgun the Falcons. The X-factor for the Dolphins may be whether Lamar Miller and Daniel Thomas can exploit Atlanta's less-than-stellar defense against the run. 

Prediction: Falcons 27, Dolphins 20

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