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Week 2 stats: 13-of-28 passing, 127 yards, three interceptions; nine carries, 87 yards
Colin Kaepernick had his worst game as a pro against Seattle.
He had never thrown more than one interception in a game, and his 20.1 passer rating was, by far, the worst of his career as a starter.
The Colts could be just what the doctor ordered.
Indy allowed 219 passing yards and 112 rushing yards to Terrelle Pryor in Week 1. To compare, Pryor only threw for 126 yards and rushed for 50 yards in Week 2 against the Jacksonville Jaguars.
The Colts then allowed 319 passing yards to Ryan Tannehill, which was the second-best total in his career.
Kaepernick showed against Seattle that he's more likely to make bad decisions when trailing by a couple of scores with the run game struggling. The 49ers aren't likely to be in that position. Expect an impressive performance.
Prediction: 18-of-26 passing, 265 yards, two touchdowns, four carries, 40 yards