Liverpool will need to be wary of Southampton.
Rooting for the underdog is a particularly English pastime, so scanning the fixture list for potential upsets is standard practice each weekend.
The fifth week of the Premier League season offers some intriguing matchups, and there are three teams in particular who should be very wary of an upset.
Paul Lambert travels back to Norfolk to visit his former team, with Norwich looking to get back on track after being convincingly beaten by Tottenham in Week 4.
Although Villa won at Carrow Road last year—in the league and Capital One Cup—they've shown themselves to be vulnerable after going down 2-1 at home to Newcastle last week. That was their third defeat in a row and Lambert will be keen to right the ship.
It should still be considered an upset if Norwich were to win, but they've spent money wisely in the offseason and look strong at home. Gary Hooper is now recovered from his shin injury and should see some time on the pitch in his first home game of the season.
It's going to be a tough game for Villa, but one that's definitely worth watching.
Wins in their first three games propelled Liverpool to the top of the table and things finally look to be coming together for dispirited Reds fans. Nevertheless, the team have a funny habit of underperforming against sides they should beat, which makes Southampton a dangerous opponent.
Liverpool won those three opening fixtures 1-0, while Southampton have found it difficult to find the net. It's likely to be another low-scoring game, which means there's a chance that new England hero Rickie Lambert could get a result for the Saints.
As they so often do, Liverpool will dominate at Anfield, controlling possession and pinning their opponents back in their own half. Where they've had trouble recently is in finishing off chances. If they fail to finish again, Southampton will always be in the game.
Buzzing off an away victory against Villa, Newcastle's frustratingly inconsistent season could continue with a trap game at home to Hull City Tigers.
Yohan Cabaye and Hatem Ben Arfa are the creative spark on which Newcastle depend for success. Papiss Cisse has failed to score this season and looks out of sorts once again. It's difficult to remember the player he was when he arrived halfway through the 2011/12 season, such is the lacklustre way he has gone about his business over the last year.
There's no reason why the Toon should lose this, but it's impossible to predict which version of the Magpies will show up. If it's last year's, there could be horses running for their lives all over Tyneside.