There are a number of storylines going into this game, especially after what transpired in Week 1 of the 2013 NFL season.
The Broncos opened their season at home by dominating the defending Super Bowl champion Baltimore Ravens with a 49-27 victory at home. Most consider it to be Week 1's best performance of any team, as CBSSports.com's Pete Prisco ranked the Broncos as the No. 1 team in the league in his weekly power rankings.
On the other hand, the New York Giants opened the season in Dallas where they were defeated by the Cowboys, 36-31. The low point of the loss was the six turnovers committed by the Giants offense.
The Broncos are an AFC contender, as are the Giants in the NFC. Peyton faces his brother Eli for the third (and likely last) time in the regular season.
Here are five storylines to watch in this highly anticipated Week 2 matchup.