All eyes will be on Alabama and Texas A&M on Saturday, but Oregon is one of the teams that will cruise to easy victories in nonconference games in Week 3.
This will arguably be the biggest week of the season before conference play really heats up, so be sure to tune in to the games this weekend.
A few of the top teams will take on teams from BCS automatic-qualifying conferences. They will be tested early, but they will be to pull away from their opponents.
Here is a schedule for the AP Top 25 followed by a few of the top teams that will cruise to victories in Week 3.
No. 2 Oregon Ducks (vs. Tennessee Volunteers)
Oregon went across the country to take on the Virginia Cavaliers and won, 59-10. It dominated its ACC opponent, and now it will be tested by a school from the SEC.
The Ducks are putting up 62.5 points and 425 rushing yards per game this year, both of which are among the best marks in the nation.
Tennessee is 2-0 this season, which is how it started off last season before facing its first ranked opponent. The Volunteers lost five of their next six and finished the season 5-7. They allowed eight different teams to score at least 37 points last year, but they didn't face anyone like Oregon.
New Ducks coach Mark Helfrich picked up right where Chip Kelly left off. Quarterback Marcus Mariota has thrown for 433 yards and run for 235 yards, and he has six total touchdowns. Speedster De'Anthony Thomas has carried the ball 29 times for 252 yards and five touchdowns.
The Ducks have too much firepower on offense for the Volunteers to handle. This game may stay close for a quarter, but Oregon is going to roll past Tennessee.
Prediction: Oregon Ducks 57, Tennessee Volunteers 21
No. 4 Ohio State Buckeyes (at Cal Golden Bears)
Ohio State still doesn't know if quarterback Braxton Miller will be in the lineup, according to ESPN.com. The Heisman candidate sprained his MCL against San Diego State last week, and he will be a game-time decision.
Even if he is not in the lineup, the Buckeyes will be fine with senior quarterback Kenny Guiton. The man the students call "Kenny G" saved last season's perfect record, and he replaced Miller last week to lead his team to a victory. He threw for 152 yards with two touchdowns, and he carried the ball nine times for 83 yards and a score.
Junior Bradley Roby returned from suspension last week to help solidify the secondary.
Cal has already lost to one Big Ten team, No. 22 Northwestern, this season, and it struggled to put away Portland State last week.
These two teams met last season in Columbus, and Ohio State escaped with a 35-28 victory thanks to a late touchdown.
The Golden Bears have a new quarterback, but running back Brendan Bigelow will look to repeat the best performance of his career. Last year's meeting was the only time that he has topped the 100-yard mark, which was aided by an 81-yard touchdown.
With or without Miller, Ohio State will cruise in this game. The Buckeyes have dropped a spot in the polls each week, so they will be looking to make a statement against a Pac-12 team.
Prediction: Ohio State Buckeyes 49, Cal 17
No. 7 Louisville Cardinals (at Kentucky Wildcats)
Louisville will travel to Lexington to take on in-state rival Kentucky on Saturday, and this game has a chance to get ugly early.
Heisman candidate Teddy Bridgewater will be looking to pad his stats against an SEC team. The junior has thrown for 752 yards and nine touchdowns in two games. He has helped the Cardinals beat the Ohio Bobcats, winners of back-to-back bowl games, and Eastern Kentucky.
The Wildcats, on the other hand, were stunned by Western Kentucky to open the season. They responded by thrashing Miami (Ohio) last week.
Louisville has allowed only seven points in each of its first two games, and the offense has put up 46.5 points per game and 545 yards per game, most of which come from Bridgewater.
Kentucky has been able to put up 308 passing yards and 239 rushing yards per game, but it hasn't gone up against a team like Louisville.
The Wildcats beat the Cardinals by seven in 2010, but the scores have gotten progressively worse for Kentucky. It lost by seven the next year and 18 last year.
Now that Bridgewater is playing at such a high level, this game won't be close.
Prediction: Louisville Cardinals 42, Kentucky Wildcats 10
*All stats are courtesy of ESPN.com.