Aside from being brothers, these two also have many things in common.
In a winning effort, Peyton took the world by storm after throwing seven touchdowns and compiling 462 yards in the Broncos' season-opening win against the defending Super Bowl champions, the Baltimore Ravens.
Eli, on the other hand, was mostly impressive with four touchdowns and 450 yards through the air, but he did throw three interceptions in the Giants' loss to the Dallas Cowboys.
Peyton utilized seven receivers during the first game of the season with the biggest beneficiaries being Demaryius Thomas, Wes Welker and upstart tight end, Julius Thomas. Like his brother, Eli connected with five different receivers, namely Victor Cruz, Rueben Randle, Hakeem Nicks and tight end Brandon Myers.
The biggest problem for these siblings is their respective rushing attacks.
The Broncos got just 65 yards on 23 carries from their backs, which included Knowshon Moreno, Montee Ball and Ronnie Hillman. Denver continues to try and figure out who is their No. 1 guy as none of this squad's options proved to be reliable enough to win the top spot.
Who ya got?
New York's problems in the backfield were much more upfront after starting back David Wilson fumbled the ball away twice against Dallas and was subsequently removed from the game after. His replacement, Da'Rel Scott, just injured his knee in practice, per Ralph Vacchiano of the New York Daily News:
The injury to Da'Rel Scott was to his knee, by the way. Stay tuned for more. He went for tests, so the seriousness is unknown. #NYG— Ralph Vacchiano (@RVacchianoNYDN) September 11, 2013
Granted, the Giants did recently sign Brandon Jacobs to help fill the void left by an unreliable run game, but it remains to be seen just how much, if anything Jacobs has left to give.
So, with all things being equal on the ground as well, it looks as though this game will come down to which Manning brother can better the other and take care of the ball more—and that's where Peyton holds an advantage over Eli.
Thanks to the injury to cornerback Champ Bailey (questionable, per ESPN.com) and linebacker Von Miller's suspension, the Broncos may not be at full strength defensively, although there's a chance Bailey plays and gives Eli's receivers problems.
However, the Giants won't be at any advantage on defense themselves, as they lack a solid secondary and their pass rush just hasn't been the same at getting to the quarterback as it was in the past.
That will allow Peyton plenty of time in the pocket to pick apart the Giants defense. Eli should enjoy somewhat of the same time to throw, but it's clear after Week 1 that the Giants offensive line is suspect at best, thus more pressure is likely and that should lead to more picks for the Giants signal-caller.
If that turns out to be the case, the Broncos will be in a great position to win thanks to extra possessions. And, as was showcased in Week 1, if you give the Broncos extra possessions, they will exploit it to the fullest extent.
Also, Peyton's no-huddle offense and long drives will keep the Giants defense on the field and extra tired throughout this contest.
This game will be close because both teams can put points on the board, but Peyton's ability to avoid making major mistakes will be the biggest edge he has in a win over Eli.