Will the defending Super Bowl champs go 0-2 after this week? What about the Green Bay Packers, who host RGIII and face the prospect of also dropping to 0-2?
The reality is real for these two teams.
The Ravens play a young Cleveland team that is only getting better from week to week. Its first-round draft pick, linebacker Barkevious Mingo, is ready to make his debut and should have an impact on slowing Joe Flacco and company down.
Robert Griffin III is done with his preseason (see: the Monday night game) and is ready to roll into Green Bay after the Redskins were smashed by Chip Kelly's new lightning offense.
Can the Packers rebound from their tough loss in San Francisco?
Josh Zerkle has five teams on upset alert this week. Let us know in the comments below if you agree or disagree, or who your team is on upset alert.