On paper, this contest should feature fireworks offensively, as both squads boast dual-threat stars at quarterback and relatively productive running backs.
Also, it certainly doesn't hurt that neither team has particularly stingy defensive units.
A year ago, Mike Shanahan's bunch took both meetings, but with new coach Chip Kelly—who put together one of college football's most explosive offenses at Oregon—now in charge in Philadelphia, there's reason for Eagles fans to be optimistic about the future.
With so many fantasy studs in play, owners will be glued to this Monday night tilt. Here's a look at how each of the big-name players will fare in this Week 1 showdown.
Despite his inconsistent body of work in 2012, Michael Vick's last visit to Washington on a Monday night can't be viewed as anything but an encouraging sign of things to come for Eagles fans.
That's because the former Pro Bowl quarterback torched the Redskins for four touchdowns through the air and another two on the ground, leading the Eagles to a lopsided victory on enemy soil.
But that was three years ago.
Since then, the Virginia native has been anything but reliable for Philadelphia, though that's at least in part due to his inability to remain healthy.
However, when he's on the field, Vick's capable of changing the outcome of virtually every game. That's why Kelly tabbed the former Atlanta Falcons star as the Eagles' starter following training camp.
Obviously, there are a number of reasons to doubt Vick as a fantasy signal-caller, but if we've learned anything since the Virginia Tech product entered the league 12 years ago, it's that he usually comes up with a big performance when he's been counted out.
That being said, for the second year in a row, Vick registered just one rushing touchdown and averaged at least an interception a game in 2012.
Projected stats: 19-35, 210 passing yards, 1 passing TD, 45 rushing yards.
The Redskins are back in business now that Robert Griffin III has been cleared to play, and if his first two career starts against the Eagles are any indication of things to come, there'll be a lot to celebrate in D.C. on Tuesday morning.
It isn't just that RG3 led the 'Skins to a pair of victories over the Eagles, it's the way in which he did so. The former Heisman Trophy recipient put together two extremely impressive performances against Philadelphia.
In the first of the two meetings, Griffin was simply outstanding, as the former No. 2 overall pick went 14-15 for 200 yards through the air, another 84 yards on the ground and four scores in the process.
Who will rush for more yards in Week 1?
Though he wasn't quite as impressive on the road in Philadelphia (16-24 for 198 yards and two touchdown passes), Griffin once again sliced and diced the Eagles' secondary apart despite not being 100 percent healthy.
Given all that information, the Redskins' franchise player figures to be a safe bet to have a big day during his return to football at FedEx Field—even if his rushing numbers aren't nearly as gaudy as they were during his rookie season.
Projected stats: 20-28, 285 passing yards, 2 passing TDs, 60 rushing yards, 1 rushing TD.
While RG3 received (and deservedly so) much of the credit for the Redskins' resurgence last season, former sixth-rounder Alfred Morris was a big reason why Washington was able to win the NFC East, as the unheralded rookie earned All-Pro honors despite arriving in D.C. without much fanfare.
Now, the secret's out on Morris and teams will be better prepared for the former Florida Atlantic star's bruising style.
After putting up over 1,600 rushing yards in 2012, no one's going to be sleeping on Morris.
Nevertheless, Griffin's return is obviously going to help distract opposing defenses. Moreover, due to RG3's recovery from a knee injury, it seems logical that Morris will receive even more carries during his sophomore season.
Morris will shine on Monday night, notching his first 100-yard effort against the Eagles.
Projected stats: 21 carries for 105 rushing yards and 1 TD.
After an up-and-down debut season as a Redskin, Pierre Garcon will once again be counted upon to be Washington's No. 1 receiver.
Though he missed six games due to injury, the former Colts standout was solid when he was on the field and his production was on pace to break the 1000-yard barrier.
It doesn't hurt that, when the 'Skins went on the road to battle the Eagles, the 27-year-old receiver authored a very impressive performance in Philadelphia, hauling in seven catches for 89 yards.
Projected stats: 6 catches for 75 yards and 1 TD.
As has been the case with the vast majority of the Eagles' top offensive weapons, the last two seasons have been forgettable ones for DeSean Jackson.
That's because, after Jackson reeled in 15 touchdowns between 2009 and 2010, the two-time Pro Bowl selection has struggled to produce. Obviously, some of that is due to the drop-off in Vick's play since then.
The Redskins haven't forgotten about when Jackson burned them at home on Monday night in 2010, and given his visible decline in terms of fantasy numbers over the course of the last two seasons, reaching 1,000 yards through the air this year won't exactly be automatic for him.
He's still got all the physical attributes required to be an elite target for Vick, but whether he can maintain that level of play for a full season—and without injury—remains to be seen.
Projected stats: 7 catches for 60 yards, with at least 1 reception of 20-plus yards.