NFL Week 1 Picks: Lines and Predictions for Every Opening Game

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NFL Week 1 Picks: Lines and Predictions for Every Opening Game
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The 2013 NFL regular season is finally here, with some of the year's best matchups unfolding in Week 1 as all 32 teams set their sights on Super Bowl XLVIII

Even though it's just Week 1, we're set for some big-time matchups as playoff contenders clash all over the place, providing opportunity for plenty of betting lines and predictions.

Let's take a look at all of the upcoming Week 1 games and predictions, in addition to dissecting some of the biggest matchups of the opening weekend.

Note: All odds courtesy of Bovada

Steven Cook's Week 1 Predictions
Matchup Time (ET) TV Location Prediction
Baltimore at Denver 8:30 p.m. NBC Sports Authority Field at Mile High Denver (W)
New England (-10.5) at Buffalo p.m. CBS Ralph Wilson Stadium New England
Cincinnati at Chicago (-3) p.m. CBS Soldier Field Cincinnati
Miami at Cleveland (-2) p.m. CBS FirstEnergy Stadium Miami
Atlanta at New Orleans (-3) p.m. Fox Mercedes-Benz Superdome New Orleans
Tampa Bay (-3) at NY Jets p.m. Fox MetLife Stadium Tampa Bay
Tennessee at Pittsburgh (-7) p.m. CBS Heinz Field Tennessee
Minnesota at Detroit (-4.5) p.m. Fox Ford Field Minnesota
NY Giants at Dallas (-3) 8:30 p.m. NBC Cowboys Stadium NY Giants
Oakland at Indianapolis (-10.5) p.m. CBS Lucas Oil Stadium Indianapolis
Seattle (-3.5) at Carolina p.m. Fox Bank of America Stadium Seattle
Kansas City (-4) at Jacksonville p.m. CBS EverBank Field Kansas City
Green Bay at San Francisco (-4.5) 4:25 p.m. Fox Candlestick Park San Francisco
Arizona at St. Louis (-4.5) 4:25 p.m. Fox Edward Jones Dome St. Louis
Philadelphia at Washington (-3.5) p.m. ESPN FedEx Field Washington
Houston (-4.5) at San Diego 10:15 p.m. ESPN Qualcomm Stadium Houston

Schedule information via ESPN 

Green Bay Packers at San Francisco 49ers

Arguably the two top teams in the NFC take center stage in a mid-afternoon clash at Candlestick Park.

It doesn't get much better than that. 

The Packers are out to get revenge on last year's playoff defeat at the hands of Colin Kaepernick and the deadly read-option, but they'll have to go into a hostile environment to do so. 

Aaron Rodgers doesn't typically let teams get the best of him two times in a row, and he's surrounded by plenty of receivers who can make plays. Whether it's Randall Cobb, James Jones or Jordy Nelson catching passes, Rodgers won't be at a shortage of options.

However, Green Bay is going up against one of the league's best defenses to start the season, and that's never a comforting dynamic.

If the 49ers can rely on their stingy defense and make opportunistic plays and Kaepernick has success with his running game setting up the pass, San Francisco should pull out the home win.

Atlanta Falcons at New Orleans Saints

The 'Niners and Packers catch much of the attention in the NFC Super Bowl conversation, but the Falcons and Saints are all too easily forgotten in that talk.

With Sean Payton back from his year-long suspension, New Orleans looks to erase a woeful 2012 season by revitalizing a turnover-prone offense and patching up one of the league's worst defenses.

Meanwhile, Atlanta folded in the playoffs yet again after being one of the NFC's top teams during the whole regular season. But with Matt Ryan happily financed for the long term and star receivers Roddy White and Julio Jones to go along with future Hall of Fame tight end Tony Gonzalez, this offense threatens to hang 40 on any opponent.

Payton has a bigger impact on Brees than goes noticed, from superior play-calling to the coach's ability to relate to his star player and keep him composed through adversity. 

Despite the Saints' woeful 2012 season, they were still able to beat Atlanta at home. That'll be the case again in 2013. 

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