That will undoubtedly be the headliner as a thrilling conclusion to the women's Grand Slam season, but the men's doubles final also takes place earlier in the day in Arthur Ashe Stadium.
That matchup pits fourth seeds Leander Paes and Radek Stepanek against the second-seeded pair of Alexander Peya and Bruno Soares.
Here is an outline of the television schedule for Day 14, along with analysis and predictions as to how these major matches will play out.
Note: Statistics and information are courtesy of USOpen.org unless otherwise indicated.
Williams Successfully Defends Title in Two Sets
Williams has been so dominant in her past two matches that it feels like blasphemy or a pure lack of logic to pick against her.
The American topped Carla Suarez Navarro 6-0, 6-0 in the quarterfinals, then carried that over to a 6-0 first-set trounce of No. 5 seed Li Na, who did ultimately manage to get three games off Williams in a losing effort.
When she won the first set against Na, though, Williams had completed a stretch in which she won 24 of 25 games over the course of three matches or so. That kind of dominance is not to be doubted.
But, Azarenka gave her plenty of trouble last year when they met in the final, when the score was 6-2, 2-6, 7-5 in favor of Williams. The Belarusian star also beat Williams in the Cincinnati Masters that preceded this year's final leg of the Grand Slam.
The 24-year-old hasn't been nearly as impressive as Williams throughout the tournament, though, and had her serve broken five times against unseeded Flavia Pennetta in the semis.
Unless Azarenka can find a way to serve better and Williams is slightly off her game, this match should feature one tiebreaker but ultimately go to Williams in two sets.
Williams wins: 7-6 (4), 6-4
Paez/Stepanek Pull Slight Upset to Capture Men's Doubles
The dominant Bryan brothers had a chance at capturing all four Grand Slam titles in 2013, but Paes and Stepanek derailed their golden opportunity to make huge history.
Paes and Stepanek dropped the first set 6-3, but rallied back to stun their No. 1-seeded opponents 6-3, 6-4 in the next two sets to advance to this stage.
One could argue that the duo will suffer a letdown from the euphoria of beating the seemingly unstoppable force that was the Bryans—and on the Americans' home soil at that.
However, Stepanek is the only truly established individual player among these four, and he and Paes have been in a similar position to this before, winning the 2012 Australian Open doubles title.
As strong as Peya and Soares have been together to claim the No. 2 seeding and reach this stage, they have never emerged victorious with Grand Slam hardware.
That will continue, as the lower-seeded pair of Paes and Stepanek claim victory in straight sets.
Paes and Stepanek win: 7-5, 6-3