The Manchester United forward was shown a yellow card after playing on just a second beyond the referee's whistle during the 4-0 win over Moldova on Friday.
However, Welbeck was also booked during the draw in Montenegro in March and will now miss the trip to Kiev next week.
But the question now is to whom will Hodgson turn as a replacement for Welbeck in the vital qualifier against Ukraine?
Here we take a look at some of the options available to the England manager.
Who do you think should replace Danny Welbeck in the England lineup against Ukraine on Tuesday? Let us know in the comments below.