The Manchester United forward was shown a yellow card after playing on just a second beyond the referee's whistle during the 4-0 win over Moldova on Friday.
However, Welbeck was also booked during the draw in Montenegro in March and will now miss the trip to Kiev next week.
But the question now is to whom will Hodgson turn as a replacement for Welbeck in the vital qualifier against Ukraine?
Here we take a look at some of the options available to the England manager.
Who do you think should replace Danny Welbeck in the England lineup against Ukraine on Tuesday? Let us know in the comments below.
The former Aston Villa and Newcastle man was a second-half substitute in the 4-0 win over Moldova and represents a reliable and stable option in the atmosphere in Kiev.
However, the 27-year-old has been hampered by a lack of playing time with City this season, with Manuel Pellegrini using him for two brief substitute appearances so far.
Milner, though, has been an England regular since making his debut against Holland in 2009 and now has 40 caps to his name.
Hodgson will also be hoping the former Chelsea forward will be fit—Sturridge is the man in form among his options to replace Welbeck.
The Anfield striker has scored five times already this season for the Reds and would be a welcome addition to the England squad for the game in Ukraine.
However, it is still a race against time for the 24-year-old and Liverpool manager Brendan Rodgers would be unlikely to risk his participation with his team topping the Premier League table with a 100 percent record.
Where Milner is the safe option, the gamble for Hodgson would be the return of Ashley Young to the starting lineup in Kiev.
The Manchester United man was hampered by injuries last season but returned to the Old Trafford starting XI in the defeat at Liverpool last weekend after making a substitute appearance against Chelsea.
Young, 28, made his England debut in 2007 and now has 29 caps and seven goals for his country. But the former Aston Villa man represents a more inconsistent option than Milner, although his attacking threat is greater than that of the City player.
Tottenham manager Andre Villas-Boas has received plaudits for the business done on the back of the Gareth Bale transfer to Real Madrid, but it is Andros Towsnend who has caught the eye so far this season for the White Hart Lane club.
The 22-year-old is in his first England squad after scoring once in Tottenham's opening four matches of the season so far.
It would be a major surprise if Hodgson turned to Townsend for a first cap in the crucial Group H match in Ukraine, but his form and playing time already has him ahead of more experienced players in the squad.
Liverpool winger Raheem Sterling represents another potential risk strategy for Hodgson ahead of the game in Kiev.
The 18-year-old was one of the stars of the show in a disappointing season for the Reds last season and he made his debut for England in the friendly defeat in Sweden in November 2012. However, that remains his only cap so far.
And, despite scoring in his first start of the season for Liverpool in the Capital One Cup win over Notts County, Sterling has only played as a substitute in two Premier League games this year.
Few would argue with the England credentials of Jermain Defoe, but the thorny subject of game time at club level again comes to the fore.
The Tottenham striker has played just 37 minutes of Premier League football this season after coming off the bench in his club's three matches so far.
However, in his only starting appearance of the season, Defoe scored twice in a 3-0 win over Dinamo Tbilisi in the Europa League qualifying round second leg at White Hart Lane.
The 30-year-old has 54 England caps to his name and has scored 19 times for his country. He would also represent an experienced figure for Hodgson in Ukraine.