The only question now is whether the matchup can be anything other than a one-sided affair.
As expected, the world No. 1 will be joined in the finals by second-seeded Azarenka, who also cruised in her semifinal against significant underdog Flavia Pennetta 6-4, 6-2 on Friday.
Sunday’s final promises to be a repeat of an epic three-set battle between the two in last year’s Open that was won by Williams 7-5 in the third.
In fact, Serena is looking to eliminate her rising rival for the third straight year at Flushing Meadows and in the process win a 17th Grand Slam title.
The American has been a terror in this Open, displaying an impressive combination of athleticism and power that has proven too much for any opponent to deal with.
For Azarenka, the significant challenge of facing Williams provides her the opportunity to win a third career Slam title and the second of a breakthrough 2013 season.
The matchup marks the ninth time the two will have met since the beginning of 2012, and their third tussle in a Slam during that same period.
It’s also the most significant battle the pair will have waged against one another. Should Williams win, it will be her fifth U.S. Open crown. If "Vika" were to pull the upset, she would add a U.S. Open to her two Australian Open titles.
The stakes are certainly high on Sunday, and watching the outcome promises to be the highlight of an already entertaining year in women’s tennis.