No. 2 Oregon will travel to Charlottesville to battle Virginia on Saturday after thumping Nicholls State in Week 1, 66-3.
In the blowout victory against the Colonels, dual-threat quarterback Marcus Mariota went 12-of-21 for 234 yards and a touchdown while rushing for 113 yards and two scores.
Running backs De'Anthony Thomas and Byron Marshall combined for 252 yards and three touchdowns on the ground, while senior receiver Josh Huff caught five balls for 118 yards.
Virginia is coming off a harrowing 19-16 victory over BYU.
The Cavaliers were trailing the Cougars with five minutes left in the game, 16-12, but took the lead for good after junior running back Kevin Parks scampered 13 yards for a touchdown with 2:36 remaining.
Virginia managed only 223 yards of total offense in the game but took the win nonetheless.
Does Virginia have what it takes to upset Oregon?
When: Saturday, Sept. 7, at 3:30 p.m. ET
Where: Scott Stadium, Charlottesville, Va.
Betting Line (via Bovada): Oregon -23
Oregon Injuries (via USA Today)
Jake Fisher, OL, Probable (Undisclosed)
Mana Greig, OL, Probable (Undisclosed)
Thomas Tyner, RB, Probable (Undisclosed)
Pharaoh Brown, TE, Questionable (Undisclosed)
Virginia Injuries (via USA Today)
Wilfred Wahee, CB, Out for Season (Knee)
Tim Harris , DB, Questionable (Leg)
Top Storyline: Can Virginia's Defense Slow Down Oregon's Up-Tempo Attack?
Virginia fans should be proud of what the Cavaliers did against BYU in Week 1, holding Cougars quarterback Taysom Hill to 4.4 yards per pass attempt.
Junior safety Anthony Harris was outstanding, racking up 11 tackles to go along with a sack, a blocked punt and an interception that set up Parks' winning score in the closing minutes.
That being said, that was Taysom Hill and BYU, and this is Marcus Mariota and Oregon. While Hill had trouble getting the ball out to his playmakers in space against the Cavaliers, that won't be much of a challenge for Mariota, who is only getting better after a spectacular freshman season last year.
Virginia has gotten off to a strong start, but the real test comes against Oregon. The defense will have to play even better than it did against BYU to contain the Ducks.
One item of concern for Virginia: While the Cavaliers did shut down the BYU passing attack in Week 1, Cougars sophomore running back Jamaal Williams rushed for 144 yards.
Prediction: Oregon 38, Virginia 14
Who will win on Saturday?
Even if Virginia does manage to slow down the passing game, the Cavaliers haven't shown they can stop the run, this year or last year. Last season, the Cavaliers allowed 3.99 yards per carry, ranked 50th in the nation.
If Jamaal Williams rushed for 144 yards, what do you think Mariota, Thomas and Marshall are going to rush for?
That's a rhetorical question. In fact, Virginia fans better not think about it at all.
Plus, Virginia's offense was pretty dismal against BYU. While Oregon didn't exactly play against the most menacing offense in Week 1, the fact that eight different players recorded a tackle for loss and six different players recorded a sack was impressive nonetheless. The Ducks' defense may have been underrated coming into the season.