Four months after that Week 1 win, San Francisco advanced in the playoffs with a 45-31 wild win at home over the Pack. Quarterback Colin Kaepernick rushed for 181 yards—an NFL playoff record for a quarterback—to lead a 579-yard attack as San Fran covered the three-point spread.
San Francisco is laying 4.5 points in this year's debut, according to most sportsbooks monitored by OddsShark.com, while the total is a consensus 48.5.
While there is plenty of intrigue surrounding Kaepernick in his second season as a starter, Green Bay field general Aaron Rodgers has his own pressures of silencing critics who have called his leadership ability into question this offseason.
Former teammates Greg Jennings and Donald Driver have spoken out against Rodgers this offseason, something that doesn't seem fitting for the highest-rated passer of all-time. Rodgers, who has a career passer rating of 104.9, is the most accurate passer in Packers history with a career completion percentage of 65.7 percent.
The Packers come in on winning ATS streaks of 5-1 in season-openers, 23-9 on a natural surface, 7-3 against NFC foes and 5-2 overall.
On the flip side, San Fran's Jim Harbaugh has led the Niners to a 24-11-2 mark at the window the past two seasons, including a 12-4-2 record at Candlestick, while his Niners are in on spread streaks of 6-1 in the opening month, 16-6 at home and 7-3 in season lid-lifters.
Green Bay has covered 11 of the last 14 meetings, including 6-of-7 in Frisco.
Computer Pick: 30-29 San Fran, according to Odds Shark Computer
Stats, trends and lines courtesy of OddsShark.com. Follow Mike Pickett on Twitter.