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A position that runs as deep as the Mariana Trench, sometimes projecting the top-five scoring wide receivers on a weekly basis can be tough.
Outside of the names who made this list, look for guys like Andre Johnson, Dwayne Bowe, Roddy White and Marques Colston to also have big weeks for fantasy owners.
1. Calvin Johnson
This week expect Megatron to be, well, Megatron. Fresh off a record-setting season where he managed to rack up 1,964 yards receiving on 122 catches, there's no reason to think Johnson isn't going to have another big campaign with the Lions in 2013.
Outside of his ability, one thing you have to like about Johnson is the guy is a target machine. Racking up 25 targets in his two appearances against the Vikings last season, nothing is going to change when these teams meet up Sunday at Ford Field.
Seeing Johnson ranked as the No. 1 wide receiver is going to be a recurring theme this season. At 6'5", there really isn't a defensive back in this league who can slow him down.
Projection: 8 receptions, 140 yards receiving, 1 TD
2. Dez Bryant
There's a real possibility that Dallas Cowboys standout Dez Bryant could end up finishing this fantasy season as the No. 2 ranked wide receiver.
The ultra-talented Bryant will look to get out of the gate fast when he lines up against the New York Giants in Week 1.
Facing last year's 28th-ranked pass defense, thanks to his physical attributes and connection with quarterback Tony Romo, nothing is going to be able to stop Bryant from putting up big numbers this week.
Projection: 7 receptions, 126 yards receiving, 1 TD
3. Julio Jones
Keeping with the theme of talented wide receivers, Atlanta Falcons superstar Julio Jones is going to have a big Week 1.
Facing the New Orleans Saints and their leaky pass defense—last season the Saints ranked 31st against the pass—nothing will stop Jones from having a monster game.
Possessing all of the skill and potential in the world, the only problem with Jones is his inconsistency in terms of fantasy football scoring.
According to Tristan H. Cockcroft of ESPN.com, last season, Jones was the biggest boom-or-bust wide receiver in all of fantasy football.
Regardless, Jones is about to take his place in a classic offensive shootout this Sunday. Playing indoors against the Saints and their questionable defense makes him a smart play for any fantasy GM.
Projection: 5 receptions, 110 yards receiving, 1 TD
4. Demaryius Thomas
With all of the talented WRs in the NFL today, sometimes it's easy to forget about Denver Broncos WR Demaryius Thomas.
Although the Broncos will battle the always tough Baltimore Ravens to start their season, all the signs for Thomas to find success are still there.
According to The Denver Post, Thomas is coming off one of his best training camps. Whether we're talking about his progression as a player or the amazing chemistry he shares with QB Peyton Manning, either way you slice it, Thomas is going to have one great fantasy football season.
Even with Wes Welker and Eric Decker on the field, the fact remains, Thomas is still the biggest and most talented target Manning has out there.
Projection: 5 receptions, 96 yards receiving, 1 TD
5. A.J. Green
Grading out as the third-most consistent WR in fantasy football last season, per ESPN.com, Cincinnati Bengals third-year stud A.J. Green is always a player who manages to put up great numbers.
Even though he has a tough matchup against the Chicago Bears—the Bears finished last season with the 8th-best pass defense in the NFL—Green's amazing talent gives him the edge any player needs when taking on a strong defense.
According to Pro Football Focus (subscription required), Green finished last season as the 8th-best wide receiver in the NFL. Now with more experience, Week 1 against the Bears is going to kickoff a huge 2013 fantasy football season for Green.
Projection: 5 receptions, 88 yards receiving, 1 TD