Before the key individual battles are assessed, here's a look at how the game will be contested.
Everton are likely to dominate possession, building from the back and hoping to invite Cardiff onto them in order to play through.
Only Manchester City have enjoyed more possession that Everton this season (64.7 percent), but Roberto Martinez's side have struggled with their tempo thus far, finding it difficult to persistently penetrate congested defences. Width will be key for the Toffees, as will a slicker, speedier passing game.
The hosts won't be too concerned with allowing Everton the lion's share of possession, especially given the success of their rearguard effort against Manchester City.
The Bluebirds have been one of the most direct Premier League sides so far, averaging the second-fewest short passes (274) per game and the second-most long balls (71). They will look to run onto knockdowns from their striker, break at pace any time Everton surrender play and attack the space left behind Seamus Coleman and Leighton Baines.
By the same token, any time the Toffees can regain possession without the two lines of four in front of them could prove the difference, as the likes of Ross Barkley and Kevin Mirallas become far more dangerous.
Set pieces will play an important part for both teams, and Everton will need to analyse how the Bluebirds scored twice from dead-ball scenarios against Manchester City.