South Carolina and North Carolina used to meet annually when both schools were members of the Atlantic Coast Conference, but meetings between the two border rivals have been rare since South Carolina left the league after the 1970 season.
The two teams have met 11 times since 1974, with the Gamecocks holding a 6-5 advantage.
The Gamecocks enter the season with the highest preseason ranking in school history (No. 6/7) and are coming off back-to-back 11-2 seasons.
The Tar Heels finished 8-4 last season under first-year head coach Larry Fedora.
Both teams enter the season with a few holes to fill. North Carolina lost three starting offensive linemen, each of whom was selected in the NFL draft.
The Tar Heels also must replace their two top wide receivers and their best running back.
South Carolina begins the year with three new linebackers, a new center and a new place kicker.
Who: North Carolina Tar Heels at South Carolina Gamecocks
When: 6 p.m. ET
Where: Williams-Brice Stadium, Columbia, S.C.
Series history: North Carolina leads 34-17-4.