Burton Albion 2-2 Fulham (4-5 penalty shootout)
Fulham survived upset-minded Burton Albion after the League Two side took the lead in extra time.
Michael Symes put Burton ahead in the 102nd minute, but Hugo Rodallega equalised for the visitors three minutes from the end of extra time. In the shootout, John Arne Riise converted the winner after Jack Dyer missed.
Leyton Orient 0-1 Hull City
Robert Brady scored the only goal in the 107th minute after the teams played out a scoreless draw in regular time. Brady had entered the match less than a minute earlier as a substitute.
Orient created the better chances at Brisbane Road, with David Mooney missing a golden chance with an errant header in the first half.
Barnsley 1-5 Southampton
Steven Davis scored twice for Southampton, who scored four times in the second half to sweep aside second-tier Barnsley. Jay Rodriguez, Emmanuel Mayuka and Gaston Ramirez added the other goals for the Saints.
Stephen Dawson pulled Barnsley within one goal early in the second half.
Norwich 6-3 Bury
Johan Elmander scored twice on his first start for Norwich in an eventful match that saw six goals in the final 18 minutes.
Martin Olsson, Anthony Pilkington, Leroy Fer and Steven Whittaker scored once each for Norwich, while Anton Forrester, William Edjenguele and Jessy Reindorf netted for the visitors from League Two.
West Ham 2-1 Cheltenham Town
Former Manchester United midfielder Ravel Morrison scored on his home debut for West Ham as the Hammers saw off determined Cheltenham.
Morrison, who spent last season on loan with Birmingham City, made it 2-0 just after half-time. Ricardo Vaz Te had opened the scoring with a free kick just before the break.
Matt Richards converted a penalty for Cheltenham.
West Bromwich Albion 3-0 Newport County
Saido Berahino hit a first-half hat-trick on his full West Brom debut to help the Baggies ease past newly promoted League Two side Newport County.
Berahino opened the scoring with a deft touch past the keeper in the seventh minute, then doubled West Brom's advantage 19 minutes later with his left foot. He finished the hat-trick with a 38th-minute penalty.