After a decade of rivalry between the two sides, Manchester United and Chelsea will enter Old Trafford tonight having both changed managers simultaneously for the first time in Premier League history.
The hotly-anticipated clash between the two giants of English football will hopefully produce the same kind of determination and excitement that the previous encounters have.
Chelsea managed to secure a crucial 1-0 victory in this fixture last season back in April, when Juan Mata's 87th-minute strike stole all three points before Manchester United defender Rafael was sent off in controversial circumstances late on.
And the Bank Holiday clash tonight is all set to be packed with action and drama, especially with Jose Mourinho at the helm.
But David Moyes is unlikely to back down as he faces his toughest test yet as Red Devils manager, and will be desperate to continue their 100 percent start to the season.
It's sure to be a magnificent game, and we've taken a look at some of the key battles ahead of the crunch encounter in Manchester, so please join the discussion by posting your views at the bottom of the page.