With Tim Hardaway Jr. and Beno Udrih now on the roster, the Knicks can get by without J.R. Smith for a few weeks, but it's the injury history of the frontcourt that they should really be worrying about.
In terms of talent, New York has arguably the deepest frontcourt in the NBA, but Amar'e Stoudemire, Andrea Bargnani and Tyson Chandler are very injury-prone, while Kenyon Martin is also a worry at this stage in his career.
They'll be hard to stop when everyone's healthy, but it's conceivable that they could go through long stretches with three or four key players out of action. In fact, there was a point late last season when Stoudemire, Chandler and Martin were all out at the same time, while Bargnani was also out of action with the Toronto Raptors.
If that happens, it will have the added effect of forcing Carmelo Anthony to guard the 4 spot more often, which didn't work out too well for his shoulder last season. After spending significant time guarding bigger players, he went into the postseason with an injury, which is a big reason why New York was knocked out in the second round of the playoffs.
There is an argument to be made that things could improve. Bargnani is still only 27, and, now that he's had a debridement performed on both knees, Stoudemire should be less of an injury risk. Still, though, there's no ignoring the significance of this problem.
Chemistry, point guard play and spacing aren't major issues any more, but injuries could well keep this team from reaching its potential and getting past the second round. This is the biggest concern the Knicks have and, unfortunately, there's not really much they can do about it.