The hosts kicked off their season with a hugely impressive 4-1 victory over Swansea City at the Liberty Stadium, with Robin van Persie and Danny Welbeck each grabbing two goals as United cantered comfortably over the finish line.
Chelsea faced newly promoted and newly renamed Hull City Tigers on the opening weekend. The Blues barely had to get out of second gear as they saw off Steve Bruce's men 2-0 in one of the more professional performances you are likely to see this year.
Jose Mourinho's side were unstoppable in the opening half an hour and, despite only scoring twice with Frank Lampard also missing an early penalty, looked like they could have gone on to hit double figures.
With the two sides both securing comfortable victories on the opening weekend, we take a look at the key men who will battle it out as two of the favourites to lift the Premier League trophy go head to head.