Chelsea created enough opportunities to overwhelm their opponent in a 2-0 victory over Hull City. They are expected to be contenders for a league title this season, and the first match did little to change this goal.
Meanwhile, Aston Villa had a more surprising performance on the road against Arsenal. They drew a red card just after the hour mark and finished with a 3-1 victory.
Both sides will now try to jump to the top of the table with three points. Here is a look at what to expect in the upcoming contest.
Where: Stamford Bridge, England
When: Wednesday, Aug. 21
Time: 2:45 p.m. ET, 7:45 p.m. BST
TV: NBC Sports
Live Stream: NBC Sports Live Extra
Chelsea: 81.4 percent
Aston Villa: 4.7 percent
Draw: 13.9 percent
*As of Aug. 24 at 9:45 a.m. ET, 12:45 p.m. BST, courtesy of Bloomberg Sports.
Chelsea Player to Watch: Eden Hazard
Last season, Eden Hazard was one of Chelsea's most productive players. He totaled nine goals and 11 assists in league play, and he combined with Juan Mata to form one of the best creative midfield duos in Europe.
However, Jose Mourinho is still not satisfied with what he has seen. According to Miguel Delaney of ESPN, the manager is concerned about Hazard wasting talent, and he wants to see "more responsibility and more ambition."
It remains to be seen how Hazard responds to this challenge, but it is clear that the talent is there for him to succeed. If he steps up his efforts, Chelsea's attack could end up being almost unstoppable.
Aston Villa Player to Watch: Christian Benteke
Christian Benteke was one of the top scorers in the Premier League last season and made a good start in his aim to repeat that feat.
The 22-year-old forward scored two goals against Arsenal, including a penalty, to help him keep pace with Robin van Persie for the league lead after one match. After scoring 19 last season, it is not out of the question for him to stay in the race.
Benteke has the size and skill to be a threat at any point, so Chelsea have to make sure they know where he is at all times. Otherwise, he will make his opponents pay with a goal or two.
Prediction: Chelsea 2, Aston Villa 1
With Benteke on the pitch, Aston Villa always have a chance to get on the scoresheet. Goalkeeper Brad Guzan also has enough skill to keep this a low-scoring match.
But Chelsea are simply too talented to lose this contest at home. The club are deep at every position, and the squad will get even better as youngsters Romelu Lukaku and Andre Schurrle get more comfortable in attack.
The Blues will create a number of opportunities in the final third, and Aston Villa are simply not good enough defensively to keep them from scoring.
Mourinho has never lost a league match at Stamford Bridge in 61 games, and that will not change on Wednesday.
Follow Rob Goldberg on Twitter for the latest breaking news and analysis.