Sunderland came out on top when the two sides met last season, grabbing a 1-0 win at Southampton and tying 1-1 at home. It was Southampton who had the better season though, finishing three spots ahead of the Black Cats.
Below is all the viewing information you need to know, as well as a match preview for this upcoming Premier League encounter.
Location: St. Mary's Stadium, Southampton, England
Date: Saturday, August 24, 2013
Time: 10 a.m. ET (3 p.m. BST)
TV Info: NBC Sports Network, DirecTV
Live Stream: NBC Sports Live Extra
Odds, courtesy of StatsInsight.com: Southampton win: 46.90%, Sunderland win: 25.19%, Draw: 27.91%
Both teams enter this game coming off different ends of a 1-0 scoreline. Southampton beat West Bromwich away from home, while Sunderland lost to Fulham in their home opener. Both sides were the better team in their respective games, with Sunderland a little unlucky not to come away with a win.
Southampton featured two new signings in its starting XI, Victor Wanyama and Dejan Lovren, with both players performing well. A few changes may be in store for this game, with no injuries for Mauricio Pochettino to worry about.
Sunderland also had a few new signings in their opening game, with Valentin Roberge, Cabral, Emanuele Giaccherini, Jozy Altidore and Ondrej Celustka all starting. Paulo Di Canio will have some decisions to make in terms of the starting lineup, as Lee Cattermole and Steven Fletcher may be fit for selection.
Here are some players to watch, and a match prediction, for this Premier League tie.
Southampton Player to Watch: Gaston Ramirez
Gaston Ramirez started the game against West Bromwich Albion on the bench after international duty with Uruguay during the week. The Southampton No. 10 will be expected to build on a decent debut season, and that means bringing his creativity to the side.
With Victor Wanyama and Morgan Schneiderlin in the midfield with him, he will get the freedom to have a big effect on the match.
Ramirez has the ability to chip in with goals, but it's his dribbling skills and eye for a pass that will add an extra element to Southampton's attack.
Sunderland Player to Watch: Jozy Altidore
Jozy Altidore is still likely to get the nod to start even if Steven Fletcher is available. Paulo Di Canio will not want to risk the Scottish international so soon in the season.
Altidore is coming off a brilliant few seasons with AZ Alkmaar, but only managed one goal in the Premier League during his loan spell with Hull City in the 2009-10 season. The American striker was unable to get off to a good start at home, and things will get certainly get tougher away at Southampton.
He could find it tough going if he is left on his own to battle Southampton's defenders, but has the ability, strength and pace to trouble his opponents if given the chance.
Southampton's midfield duo of Victor Wanyama and Morgan Schneiderlin will stifle any creativity that Sunderland can muster in midfield and allow Gaston Ramirez to take control of the game. If that happens, and the Saints win the battle out wide, it will be tough going for the visiting side.
Southampton can count on players like Gaston Ramirez, Ricky Lambert and Adam Lallana to influence things in an attacking sense, and those players will have a major impact in their home opener.
Southampton 3, Sunderland 1