Injuries are an unfortunate fact of life in the National Football League.
Many teams are finding this out the hard way. The first game of the 2013 preseason hasn't even been played yet and already a number of squads are dealing with significant injuries.
For some, the injuries happened in camp. Others still are the result of offseason surgery.
The circumstances of these injuries may differ, but they all share one thing in common. In each case someone is going to have to step in and pick up the slack.
For the fortunate few, reserves are in place that go a long way towards softening the blow. Others aren't so lucky, and enter the season facing many more question marks.
With that in mind, here's a look at some of the more significant injuries around the NFL, the next man up, and how much confidence that player should inspire in fans.