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They call it the "Superclasico" for good reason, as this rivalry is certainly not for the faint hearted.
Rated as the number one sporting event to attend before you die (via The Observer), this derby has everything you want in a fierce encounter.
The two top teams in Argentina hold the lions share of supporters with Boca currently attracting 40 percent of the nation and River Plate not far behind with 33 percent.
As with all these rivalries, the numbers are very close. The two have met exactly 200 times in the league with Boca Juniors holding the slight advantage with 72 wins to River’s 66.
Boca fans refer to River Plate’s supporters as "gallinas" (chickens), claiming the players show a distinct lack of guts on the pitch while the opposition refer to their counterparts as "los chanchitos" (little pigs).
And although the name-calling is more lighthearted and amusing to the neutral fan, the trouble and violence that is often associated with these matches is certainly not.
The worst occasion was on June 23, 1968 when 71 fans died and a further 150 were injured in a crush at Gate 12. The average age of the victims was just 19.
Fireworks, flare, talent and trouble, this game has everything you want to make this rivalry the biggest in the world.
The two next meet on October 5. Tune in if you get the chance, it’s a must watch. Better still, buy a ticket!