Despite being one of the most evasive fighters in the history of the sport, Silva was knocked out by challenger Chris Weidman whilst attempting to mock his opponent's apparently inferiority in the striking department.
Weidman became the first man not named Silva to strap the UFC middleweight title around his waist since 2006.
Also on the card, former UFC lightweight champion Frankie Edgar got back to his winning ways after winning a fun matchup with jiu-jitsu ace Charles Oliveira.
Chris Weidman def. Anderson Silva via knockout at 1:18 of Round 2. With this victory, he becomes the new UFC middleweight champion.
Frankie Edgar def. Charles Oliveira via unanimous decision (30-27, 29-28, 30-27)
Tim Kennedy def. Roger Gracie via unanimous decision (30-27, 30-27, 29-28)
Mark Munoz def. Tim Boetsch via unanimous decision (30-26, 30-27, 29-28)
Cub Swanson def. Dennis Siver via TKO (punches) at 2:24 of Round 3
Andrew Craig def. Chris Leben via split decision (29-28, 28-29, 30-27)
Norman Parke def. Kazuki Tokudome via unanimous decision (30-27, 30-27, 29-28)
Gabriel Gonzaga def. Dave Herman via technical knockout (punches) at 0:17 of Round 1
Edson Barboza def. Rafaello Oliveira via technical knockout (leg kicks) at 1:44 of Round 2.
Brian Melancon def. Seth Baczynski via knockout (punches) at 4:59 of Round 1.
Mike Pierce def. David Mitchell via technical knockout (punches) at 2:55 of Round 2.