Moyes has perhaps the biggest shoes in English football to fill as he takes over for the retiring Alex Ferguson, and there is plenty awaiting his attention as he takes up the job.
Here are the first five issues he'll have to attend to.
First and foremost seems to be the pressing issue of Wayne Rooney.
The Manchester United striker has been a fixture in the Red Devils team since leaving Everton—managed by Moyes at the time of course—but he lost his place last term and ended the season under a cloud, amid reports of having handed in a transfer request.
On the other hand, if he decides he's now expendable, he'll need to attend to his replacement.
One of the early transfer stories involving David Moyes as a Manchester United manager is that of Leighton Baines.
Formerly Moyes' first-choice left-back at Everton, Baines is reported to be the subject of a bid from United, as per the Guardian, but it is not yet clear how high United will have to go to be able to prise the England international away.
In the meantime, Patrice Evra is the established left-back at United, whilst Fabio Da Silva and Alexander Buttner are also part of the first team scene.
United needs two, so even if Fabio heads out on loan as he did last season, one more will still need to make way for Baines to arrive. It would be a big opening decision for Moyes to dispense with Evra, one of Ferguson's cornerstones of the team over the past few seasons.
Aside from first-team players, Moyes also has to look at the bloated United squad and decide which non-regulars are worth culling.
Nani seems to be an obvious choice after his lack of game time last season, but United also has the likes of Bebe and Federico Macheda to choose from. Neither seems to be a part of the club's future, yet they remain on the books. One or two more squad players might also leave if Moyes is intending to bring in another couple of his own signings.
Anderson could be another one of those seen as dispensable if United goes after a big-name central midfielder.
United has a big reputation to uphold, in all competitions.
Moyes will have a lot to get to grips with as he takes over for the first time and one of his first real challenges, once the season gets underway, will be to balance competing and being successful in two major tournaments.
As the season goes on, it may well be that Moyes has to decide whether he aims to continue United's domestic success while he builds more slowly toward a tilt at European glory, or whether he perhaps sacrifices the odd league game to put everything into trying to win the Champions League.
There is one final tricky and delicate issue that Moyes has to deal with.
That is, when the inevitable questions arise about how he feels to be replacing Alex Ferguson, when questions are asked of why he is doing things differently and when comparisons are drawn up between the two.
Moyes has to be able to strike a balance; somewhere between being deferential and respectful for what his predecessor achieved, and being forceful enough to make it clear that what happened beforehand is now firmly in the past.
Get the tone or words wrong and he stands to alienate some supporters or even players, while the media will no doubtedly try to take the slightest significance out of context if it suits them to do so. It's a tricky one, but one that Moyes will be well coached in trying to negotiate without problems.