The former Everton boss, who officially takes over from Sir Alex Ferguson today, has drafted Steve Round, Chris Woods and Jimmy Lumsden into his backroom squad as he prepares for his new role with United.
Round has been named as Moyes' assistant manager, a role he held at Goodison Park since 2008 when he replaced Alan Irvine, who had become Preston North End boss during the previous season.
Former England international Woods, 52, will take up the role of goalkeeping coach with United where he will be working with David de Gea, while Lumsden, 65, will take up a general coaching role at Old Trafford.
I have worked with Steve, Chris and Jimmy for a number of years and I am delighted they have decided to join me at this great club.
They bring great qualities in their respective fields and I know that, like me, they feel that this is a challenge to relish. I have great faith that together, we can build upon the success this club has enjoyed over many years.
The appointment of Round, though, is a significant one for Moyes and United, even if it is not the most unexpected arrival at the Premier League champions this summer.
Like many successful coaches before him, Round's career as a player barely left the ground. He made nine league appearances as a full-back for Derby County before his time as a professional was cut short by injury.
Round became a coach at Pride Park where he came into contact with Steve McClaren, who would subsequently take his former teammate with him to Middlesbrough when he was appointed manager at the Riverside Stadium in 2001.
When McClaren was named England head coach to replace Sven-Goran Eriksson in 2006, Round took up a dual role with the Teessiders and the national team.
In his first season at Goodison, Round helped Moyes guide Everton to the FA Cup final against Chelsea after defeating Manchester United in the semifinals.
Like Moyes, however, Round is facing the most serious test of his coaching career.
While the manager is succeeding the phenomenal 26-year tenure of Ferguson, the new Old Trafford No. 2 has his own shoes to fill replacing Mike Phelan, who helped to oversee three Premier League title wins, a Club World Cup, two League Cups and two Champions League final appearances.
The manager-assistant manager axis at any club is a crucial component, though, as Derby and Nottingham Forest supporters will testify after the success of the Brian Clough-Peter Taylor partnership at both clubs during the 1970s.
And Moyes' decision to release Phelan and goalkeeping coach Eric Steele last month (via The Guardian) was viewed as an immediate testament of his belief in the relationship with Round.
The knock-on effect for Everton and their new manager, Roberto Martinez, will also be significant.
The former Wigan Athletic boss has succeeded Moyes in the Goodison Park hotseat and now has a free rein to land his own backroom staff.