Add in the injuries to noted stars like Jo-Wilfried Tsonga, John Isner, Marin Cilic, Radek Stepanek (all noted here by the AP via ESPN) and Victoria Azarenka (from the AP via Sports Illustrated) and things are certainly going to get interesting in London over the next few days.
Just look at this tweet from ESPN Tennis:
So goes Wimbledon.
Top seeds abound in both the women's and men's draw even though Nadal and Sharapova are gone, but there's a buzz about the potential for continuing upsets that won't be squashed until the final point is won on Centre Court.
As Wednesday at the tournament continues, and we continue to lose names from the draw over the next few days, here's a look at a few potential matches of interest moving across the draw.
Sloane Stephens vs. Petra Cetkovska
This pair battled last year at Wimbledon in the second round, and it looks like they will do so again in the third round at the 2013 event.
Stephens is a rising star for the United States, and made it to the third round by taking out Andrea Petkovic in a three-set thriller on Wednesday afternoon. Cetkovaska won here third round match too; she made things even more interesting in the bottom half of the women's draw by beating Caroline Wozniacki in straight sets.
Stephens and Cetkovska went to three sets last year in the second round, with Stephens taking home the victory before falling in the next round. This year, a spot in the fourth round is on the line, and with it an adjacent shot at making the quarterfinals at Wimbledon—no easy task in today's draw.
We all know that Serena Williams is the class of the women's singles draw, and even more so now that the two players seeded directly below her (Azarenka and Sharapova) are headed home, but there's still plenty of good tennis to be had and a new crop of Wimbledon semifinalists could very well emerge from the ashes of the top seeds' demise.
We'll have to see which path forges ahead and which one tails back to the hotel room after this third-round battle.
"Potential" is the choice word here because of all the early upsets and injuries we've seen at Wimbledon so far, but Murray and FedEx appear headed for a crash course with each other yet again, with championship implications on the line.
The Brit has won three of the last four meetings between the two, but Federer won the previous three before that. Of those seven matches, only two have come on grass, where Federer beat Murray in the final at Wimbledon in 2012 and Murray promptly returned the favor at the Olympics a few weeks later.
Murray also has a win at the Australian Open semifinals on his ledger over Federer this year, and the matchup between the two is hitting a point where it's really hit or miss about which man has the upper hand.
This match wouldn't happen until the quarterfinals this year, meaning the possibility of all four top seeds advancing (Novak Djokovic and David Ferrer being the others) will no longer be intact.
But with Nadal out of the mix as a potential semifinal opponent, this match could be a play-in one for the shot at the champion from the top-half of the draw. There's a lot of tennis left to play before this happens (including Federer's second-round match on Wednesday) but this is a match to look forward to if you love Wimbledon and tennis in general.
Eugenie Bouchard vs. Petra Kvitova
Bounced in the second round at the French Open this year, Eugenie Bouchard got off to a rough start after she was poised to make some noise on the big-girl circuit.
She's back in form and ready to make that noise here at Wimbledon.
The 19-year-old Canadian has won both of her first two matches at Wimbledon in impressive fashion—she won a three-set thriller against Galina Voskoboeva her first time out, and knocked off former World No. 1 Ana Ivanovic in straight sets during Wednesday's second round.
Wimbledon's Twitter account is already pondering her greatness in the making:
Bouchard has a match with Carla Suarez Navarro before she can start glimpsing into the fourth round, but if and when she does win her third-round match, it's likely her opponent will be a former Wimbledon champion.
Petra Kvitova is just two years from her Wimbledon victory, and although she too has a tough match in the third round (Ekaterina Makarova), the eighth-seeded Czech player should prove to have the upper hand toward the fourth round.
Who wins the women's singles draw?
Bouchard is truly and up-and-comer right now, and with the top seeds faltering early, a surprise run toward the semis would be a fun storyline to follow surrounding the 2012 Junior Wimbledon champion. On the flip side, the experience and talent of the 23-year-old Kvitova will be tough to match.
It should be a good gauge for both women with respect to their Wimbledon chances, and give us a glimpse at the future of the sport on the women's side.
Follow Bleacher Report FC Ethan Grant (@DowntownEG) on Twitter.