But not every top seed was so fortunate, as British up-and-comer Laura Robson pulled off the day's biggest upset, taking out ranked Russian Maria Kirilenko in straight sets to give the hometown tennis fans something to cheer about during Andy Murray's off day.
Here we'll get you caught up on anything you may have missed Tuesday at the All England Club.
Notable Day 2 Results
|Men's Singles Draw||Score|
|Novak Djokovic (1) defeats Florian Mayer||6-3, 7-5, 6-4|
|David Ferrer (4) defeats Martin Alund||6-1, 4-6, 7-5, 6-2|
|Tomas Berdych (7) defeats Martin Klizan||6-3, 6-4, 6-4|
|Juan Martin del Potro (8) defeats Albert Ramos||6-2, 7-5, 6-1|
|Richard Gasquet (9) defeats Marcel Granollers||6-7 (2-7), 6-4, 7-5, 6-4|
|Tommy Haas (13) defeats Dmitry Tursunov||6-3, 7-5, 7-5|
|Ivan Dodig defeats Philipp Kohlschreiber (16)||4-6, 6-7 (6-8), 7-6 (7-3), 6-3, 2-1, retired|
|Bernard Tomic defeats Sam Querrey (21)||7-6 (8-6), 7-6 (7-3), 3-6, 2-6, 6-3|
|Andreas Seppi (23) defeats Denis Istomin||7-6 (8-6), 7-6 (7-3), 5-7, 3-6, 6-3|
|Jeremy Chardy (28) defeats Ryan Harrison||7-6 (7-4), 4-6, 7-5, 6-2|
|James Blake defeats Thiemo De Bakker||6-1, 6-3, 6-2|
|Women's Singles Draw||Score|
|Serena Williams (1) defeats Mandy Minella||6-1, 6-3|
|Agnieszka Radwanska (4) defeats Yvonne Meusburger||6-1, 6-1|
|Li Na (6) defeats Michaella Krajicek||6-1, 6-1|
|Angelique Kerber (7) defeats Bethanie Mattek-Sands||6-3, 6-4|
|Laura Robson defeats Maria Kirilenko (10)||6-3, 6-4|
|Roberta Vinci (11) defeats Chanelle Scheepers||6-2, 6-1|
|Karolina Pliskova defeats Nadia Petrova (13)||6-3, 6-2|
|Samantha Stosur (14) defeats Anna Schmiedlova||6-1, 6-3|
|Dominika Cibulkova (18) defeats Maria Elena Camerin||6-4, 4-6, 6-4|
|Sabine Lisicki (23) defeats Francesca Schiavone||6-1, 6-2|
|Madison Keys defeats Heather Watson||6-3, 7-5|
Serena Williams Opens with a Bang
As expected, defending women's champion and current world No. 1 Serena Williams rolled in her first-round match Tuesday, defeating Mandy Minella in straight sets, 6-1, 6-3, to extend her impressive winning streak, via the Wimbledon Twitter feed:
Williams hit 25 winners, including seven aces, in a match that lasted less than an hour.
Williams finished off the opening frame in just 20 minutes, winning every single one of her service points in the set, via the Wimbledon Twitter feed:
Minella was surprisingly able to break Williams in the second set, but the American returned the favor, breaking the over-matched underdog three times in the frame to win comfortably.
Williams will face a familiar foe in Round 2. For the second straight Grand Slam, the world No. 1 will battle Caroline Garcia in the second round. Williams beat Garcia 6-1, 6-2 in the second round of the French Open earlier this year and should have an easy time against her again Thursday as she's officially in cruise control on the All England Club grass.
Serena Williams wins 1st-rd match at Wimbledon, extends win streak to 32 matches overall, and improves to 25-1 at Wimbledon since '09.— ESPN Stats & Info (@ESPNStatsInfo) June 25, 2013
Novak Djokovic Easily Advances on Centre Court
Men's overall top seed Novak Djokovic had no trouble disposing of 2012 Wimbledon quarterfinalist Florian Mayer on Centre Court on Tuesday, beating the 29-year-old German in straight sets to advance to the second round.
The 2011 Wimbledon men's champion was incredibly productive during his service games on Day 2, winning 75 percent of his first-serve points and 81 percent of his second-serve points.
He recorded 40 winners to just 20 unforced errors for the match.
Djokovic will take on the winner of the unseeded American battle between Bobby Reynolds and Steve later this week. Djokovic hasn't lost in the second round at Wimbledon since 2008, when he was beaten in straight sets by Marat Safin.
Laura Robson Fires Up British with Upset Win
Unseeded British teenager Laura Robson gave the crowd surrounding Court No. 1 plenty to smile about Tuesday.
Robson upset 10th-seeded Maria Kirilenko, beating the Russian in straight sets to earn her second career match win in the main draw at the All England Club. Many highlighted Robson coming in as a dark-horse contender, but the dominant fashion in which she won came as a shock.
The 19-year-old won 3-of-6 break points and hit 31 winners to Kirilenko's eight, cruising 6-3, 6-4.
Up next for the hometown favorite is Colombia's Mariana Duque-Marino, who needed three sets to survive Julia Goerges in the first round on Day 2. Robson will be favored in that match, though, especially after Tuesday's confidence-boosting win, via the Wimbledon Twitter feed:
Robson's best Grand Slam finish came at the U.S. Open last summer, when she reached the round of 16 in Flushing Meadows. After defeating a former Wimbledon quarterfinalist in Kirilenko, though, Robson will have a real shot to play into the second week.
David Ferrer Slips Twice But Holds On to Win
2013 French Open finalist David Ferrer struggled to adapt to the slick grass Tuesday at Wimbledon, taking some awkward falls. But the Spaniard was able to recover, defeating unseeded opponent Martin Alund in four sets to advance to the second round.
Ferrer, who's seeded fourth and reached the quarterfinals at the All England Club for the first time in his career in 2012, won 84 percent of his first-serve points and won 50 percent (6-of-12) of his break points to knock off the upset-minded Argentine.
The 31-year-old Ferrer will play fellow Spaniard Roberto Bautista Agut in the second round.
Juan Martin del Potro Looks Strong in Grand Slam Return
Former U.S. Open men's champion Juan Martin del Potro looked impressive Tuesday at Wimbledon, making his first Grand Slam appearance since the 2013 Australian Open and winning his first Slam match since the second round in Melbourne last January.
Del Potro defeated Albert Ramos in straight sets, dropping just eight games in all.
The performance was an impressive one from the Argentine star considering how much he has struggled as of late. He skipped the French Open earlier this year while recovering from a respiratory virus and hadn't been himself since making a deep run to the final at Indian Wells in March.
The 6'6" del Potro connected on 34 winners (10 aces) while committing just 10 unforced errors against Ramos and should be considered a threat in David Ferrer's quarter of the draw. He's reached the round of 16 at the All England Club in each of the past two years.
Next up for the eighth-seeded Argentine is unseeded Canadian Jesse Levine.
Follow Bleacher Report Featured Columnist Patrick Clarke on Twitter.