Spain vs. Republic of Ireland
Venue: Yankee Stadium, New York
Date: Wednesday, 12 June (BST)
Kick-off: 8pm ET/1am BST
The reigning world and European champions have had a mixed bag of results recently with a 1-1 shock home draw in World Cup Qualifying Group I at home to Finland followed by a 1-0 victory in France, which has helped to edge the Spanish above their rivals by a point at the top of the table.
The Republic of Ireland will go into the game after two solid victories over Georgia and the Faroe Islands.
Giovanni Trappatoni's team hit a 7-0 aggregate across the two matches after drawing 1-1 with England in a friendly at Wembley.
The World Cup win over the Faroes raised hopes of an appearance at the 2014 World Cup Finals in Brazil, via the playoffs, as the team moved level at 11 points with Austria in Group C, five points behind leaders Germany.
Spain rattled four goals past the Irish when the two sides met in the European Championship Finals a year ago.
The previous meeting between the two countries came in the 2002 World Cup Finals, where the Republic produced a creditable 1-1 draw in Suwon, South Korea, when Robbie Keane's 90th-minute penalty secured a point for Mick McCarthy's team after Fernando Morientes gave Spain an early lead.
Player to watch
LA Galaxy striker Robbie Keane became the most-capped Republic of Ireland international with his 126th game in the win over the Faroe Islands, and he will be a familiar face for the crowd.
Trappatoni, himself, believes the game against Spain represents an opportunity to display his progress to the world, as BBC Sport reported.
Yesterday I said, 'James, in this game you have this great opportunity to play against the famous and most important players,' because I became famous when I was like James.
I played against Pele, Cruyff, Eusebio. They were the best players in the world. I grew because I took confidence because I could play against them.
I told McCarthy he must believe. He has vision, he has good shooting, but he can be more enterprising.