In all likelihood, they'll address the signal-caller position early, but no one is quite sure which quarterback they prefer and when they'll select him.
However, other holes exist for this club that went 6-10 in 2012 and hasn't made the postseason since the 1999-2000 season.
Here, you'll find one last mock draft before the Bills go on the clock in Round 1.
The familiarity between Ryan Nassib, Buffalo Bills head coach Doug Marrone and offensive coordinator Nate Hackett is well documented, and it carried significant weight in the decision to make him the team's first-round pick.
Nassib won't be forced to learn a totally new system with foreign terminology and different reads—all things that can stunt a rookie quarterback's growth early in his NFL career.
But the Syracuse tie isn't the only reason Nassib was the pick here at No. 8.
He has one of the stronger, more accurate arms in the class and drifts around the pocket well, improvising when pressure mounts from any direction.
His downfield touch needs to be refined, but the rest of his game is relatively sound.
After grabbing the guy they hope will be their franchise quarterback in Ryan Nassib, the Bills give their young signal-caller a threatening outside receiving weapon in Da'Rick Rogers.
He began his career at Tennessee, but after a few failed drug tests, he was forced to leave the storied SEC school.
During his one year as a starter with the Volunteers, Rogers accumulated 1,040 yards on 67 receptions with nine touchdowns.
He transferred to Tennessee Tech and caught 63 passes for 893 yards with 10 scores in 2012.
The 6'2'', 217-pound Rogers is a ferocious competitor, and his inherent aggression shows on tape. He fights for and typically wins every jump ball, he isn't timid running across the middle, and he's a strong run-blocker.
As an athlete, Rogers doesn't leave much to be desired either.
He ran a 4.52 in the 40-yard dash at the NFL Scouting Combine and had a vertical jump of 39.5 inches.
Along with careful route-running and sturdy hands, Rogers excels after the catch with an above-average burst and elusiveness.
He is an ideal outside receiver to pair with new slot man Stevie Johnson.
The Bills added linebacker Manny Lawson in free agency, but there is still a need for depth at his position.
Kevin Reddick may not be the most instinctive or decisive linebacker in the class; however, he exudes athleticism and moves exceptionally well for someone his size at 6'1'', 243 pounds.
These are his strengths: attacking the line of scrimmage, fluidly sifting around blocks to find the ball-carrier and utilizing his deceptive acceleration on delayed blitzes from the inside.
He isn't well versed in the nuances of dropping into coverage, but he's physically capable of being a fine cover linebacker in the future.
Lastly, and probably most importantly for defensive coordinator Mike Pettine, Reddick can line up on the edge of the defensive line and rush the quarterback with an assortment of seemingly natural pass-rushing skills and pure speed.
At 6'2'' and 202 pounds, Tharold Simon possesses prototypical size to be that new-age NFL cornerback who matches up physically with the more imposing outside receivers at the professional level.
He had 22 pass breakups and seven interceptions over the last three years at LSU and is exceptionally aggressive at the line of scrimmage and when the ball is approaching its intended target.
Although his technique as a press corner could be cleaned up, he has a special blend of size, athleticism and tenacity that fits perfectly into the style of play Mike Pettine has infused into the Bills defense.
In most cases, kicking a collegiate offensive tackle inside to guard in the NFL works out well. That's the Bills' plan here with Jordan Mills.
(Remember, Andy Levitre was Oregon State's left tackle before he was moved to guard in Buffalo.)
Mills was an All-WAC performer at right tackle for the Bulldogs, and at 6'5'', 315 pounds, he would be a mauling left guard next to Cordy Glenn and Eric Wood on the Bills offensive line.
He moves relatively well for his size, but his brute strength is the most noticeable positive of his game, something that will be highlighted on the interior as a guard.
With Corey McIntyre still un-signed, the Bills add an H-back to their offense who will provide versatility as a blocker and pass-catcher.
While at Harvard, Kyle Juszczyk played tight end and recorded a team high 52 receptions for 706 yards and eight touchdowns in 2012.
He ran a 4.72 in the 40 at Harvard's pro day and had a 37-inch vertical jump at 248 pounds.
Juszczyk is the perfect flier at this juncture of the draft.