It is customary to make a nod to classic encounters between these two clubs in the Premier League era whenever they meet, but they meet in darker moods than usual this weekend.
Newcastle United are only two places above the relegation zone and can still go down in more than just theory. Admittedly, no one has really seen them as realistic candidates for a drop into the Championship all season, but that threat is still there and will haunt the club until it disappears with a win.
Liverpool―who will enter this game at St James' Park in seventh place―have now seen all hope of European football next season pretty much disappear, with the only thing left to play for being the challenge to finish above Everton―something of little consequence outside Merseyside.
Regardless of that, boss Brendan Rodgers will be desperate to deliver a win following what has been yet another trying week in the recent life of Liverpool Football Club, and with the Reds having drawn all three matches they've played so far in April, that need for a win should be apparent.
In the black and white corner, Alan Pardew's Newcastle side will be desperate to put on a show for their home fans after they lost the Tyne-Wear derby with Sunderland 3-0 in their last St. James's Park contest.
Start slowly here, and they are likely to hear the backlash from some of their fans, especially given that they'll be facing a team who'll be without their star striker for well-publicized reasons.
So, both teams enter the game with a lot on their minds...