Barkley went down with a shoulder injury which prevented him from playing in USC's final regular-season game against Notre Dame and the Sun Bowl against Georgia Tech.
Before the injury, Barkley had thrown for 3,273 yards and an impressive 36 touchdowns.
While the ceiling is high for Barkley, the floor is just as low, making him the perfect example of a high-risk, high-reward selection.
Let's take a look at a couple teams Barkley has been linked to and how he will fit with each.
ESPN's Todd McShay opened up on Friday, revealing that he has heard that the Buffalo Bills like Matt Barkley.
Buffalo would make for quite the landing spot for Barkley.
Currently, the Bills have Kevin Kolb and Tarvaris Jackson as quarterbacks. These two aren't exactly household names, so Barkley could come in and have a chance to compete for the starting position.
The leash will be tight for Kolb and Jackson.
The Bills running game consists of the duo of C.J. Spiller and Fred Jackson, one who can cut and slash while the other can pound, respectively.
This bodes well for Barkley's pocket-passing style. He would be asked to sit back and throw the ball at a consistent rate and not extend plays or create with his feet, something the running backs can take care of.
Barkley will have a deep-threat wide receiver in Stevie Johnson and a reliable tight end in Scott Chandler who can bail him out in dire situations.
If Barkley were to be selected by the Bills, he would step right in and have a chance to prove his skill set that so many scouts doubt.
Granted, he will have to get used to the change in weather from sunny California to frigid Buffalo, New York.
Rob Rang of CBSSports.com has the Jacksonville Jaguars selecting Matt Barkley with the first pick in the second round, the No. 33 selection overall.
Like Buffalo, Jacksonville has quarterbacks with minor experience who can be easily replaced, such as Chad Henne.
The Jaguars, who have been lacking a consistent quarterback for years now, may be operating under the theory that the more quarterbacks they bring in, the better shot they have of finding a reliable starter.
Jacksonville relies on Maurice Jones-Drew to carry the bulk of their offense, so Barkley would be asked to control the game, something he did well at USC.
Barkley has the advantage over other quarterbacks in the draft in that his offense in college was run very similarly to that of an NFL offense.
Barkley would have a potential future star wide receiver in Justin Blackmon by his side, and the two could be a dynamic threat for years to come.
In Jacksonville, Matt Barkley would have to demonstrate his valuable intangible asset of leadership to gain a leg up on the not-so-flashy quarterback competition and gain the trust of his peers and coaching staff.