Sergio Ramos, Xabi Alonso and Angel di Maria were among those not to feature.
Of those who did though, Mesut Ozil and Cristiano Ronaldo were big enough names to get the job done against a Betis side, who came into the match still harboring European ambitions.
Ozil opened the scoring just before the break before Karim Benzema added a second after it. Jorge Molina then pulled one back from the penalty spot, and, for a while, the visitor's tails were up.
In stoppage time though, Ozil added his second of the night as Real Madrid recorded a 3-1 win.
Here are some talking points to come out of the match...