Spurs host the champions this weekend in a pivotal game that will have a huge bearing on their Champions League qualification fate.
Andre Villas-Boas has been stunned in recent weeks by the injury to Gareth Bale, and with a slump in results combined with their rivals picking up form, The Lilywhites have dropped out of the top four.
City do not have much to play for in the league since the title appears to almost certainly be heading to the other side of Manchester, and the probability of two sides usurping them and forcing them into fourth place and thus a Champions League playoff appear remote.
Roberto Mancini is a proud man who will want his side to finish strong and reduce the gap between themselves and United to a respectable amount to maintain some pride in the defence of their crown.
It should be a gripping game that will have a bearing on several sides in and around the European places. Here is all you need to know.
GARETH BALE UPDATE: Spurs are now confident that Bale will be able to face City this weekend. Andre Villas-Boas revealed "He's made good progress to train with the team so I think he'll definitely be up for selection" (via BBC).